TY - JOUR
T1 - Reporting only relative effect measures was potentially misleading
T2 - some good practices for improving the soundness of epidemiological results
AU - Novelli, Marco
AU - Baldi Antognini, Alessandro
AU - Boffetta, Paolo
AU - Ioannidis, John PA
AU - Spatari, Giovanna
AU - Violante, Francesco S.
N1 - Publisher Copyright:
© 2021
PY - 2021/9
Y1 - 2021/9
N2 - Objective: In the medical and epidemiological literature there is a growing tendency to report an excessive number of decimal digits (often three, sometimes four), especially when measures of relative occurrence are small; this can be misleading. Study Design and Setting: We combined mathematical and statistical reasoning about the precision of relative risks with the meaning of the decimal part of the same measures from biological and public health perspectives. Results: We identified a general rule for minimizing the mathematical error due to rounding of relative risks, depending on the background absolute rate, which justifies the use of one or more decimal digits for estimates close to 1. Conclusions: We suggest that both relative and absolute risk measures (expressed as a rates) should be reported, and two decimal digits should be used for relative risk close to 1 only if the background rate is at least 1/1,000 py. The use of more than two decimal digits is justified only when the background rate is high (ie, 1/10 py).
AB - Objective: In the medical and epidemiological literature there is a growing tendency to report an excessive number of decimal digits (often three, sometimes four), especially when measures of relative occurrence are small; this can be misleading. Study Design and Setting: We combined mathematical and statistical reasoning about the precision of relative risks with the meaning of the decimal part of the same measures from biological and public health perspectives. Results: We identified a general rule for minimizing the mathematical error due to rounding of relative risks, depending on the background absolute rate, which justifies the use of one or more decimal digits for estimates close to 1. Conclusions: We suggest that both relative and absolute risk measures (expressed as a rates) should be reported, and two decimal digits should be used for relative risk close to 1 only if the background rate is at least 1/1,000 py. The use of more than two decimal digits is justified only when the background rate is high (ie, 1/10 py).
KW - Observational studies
KW - Relative risk
KW - Rounding error, Odds ratio, Confidence intervals
KW - Statistical precision
UR - https://www.scopus.com/pages/publications/85106289953
U2 - 10.1016/j.jclinepi.2021.04.006
DO - 10.1016/j.jclinepi.2021.04.006
M3 - Article
C2 - 33894329
AN - SCOPUS:85106289953
SN - 0895-4356
VL - 137
SP - 195
EP - 199
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
ER -