Report of the DNA committee and catalogues of cloned and mapped genes, markers formatted for PCR and DNA polymorphisms

1. Guidance is given for the selection of reference markers by the Chromosome Workshops, and their entry into GDB using Map Manager, as an interim set of DNA segments and sequences providing a framework map within which other markers and sites may be positioned 2. Criteria for issuing D-numbers are restated. Il is recommended that Chromosome Committee Chairs should be consulted about assignment of new D-numbcrs to markers which are not polymorphic when there are already many markers on a chromosome. It is recommended that polymorphic markers should be linked either physically or genetically to an existing marker before submission if possible. 3. It is recommended that the Tables which are now published as part of the DNA Committee Report should be converted from cytogenetic location order into map order by the next Human Genome Workshop, and that wherever possible markers and sites should be presented as a linear array relative to the framework provided by reference markers. Chromosome Committees and Chromosome Workshops should liaise with the DNA Committee to determine priorities for this during the coming year. 4. It is recommended thai the DNA Committee continue as a major advisory committee to Human Genome Workshops and individual Chromosome Workshops, in order to provide policy guidelines from the genetics communities on the mapping of DNA polymorphisms, sequences and sites, their integration into databases and for other uses.