Abstract
The NIH 3T3-derived cell line ψAM22b, which carries a defective Moloney murine leukemia virus, was transfected with a plasmid carrying the neo gene and two head-to-tail copies of the hepatitis B virus (HBV) genome positioned with opposing polarities. Both the two HBV dimers and the neo gene were located between two Moloney murine leukemia virus long terminal repeats. Poly(A)+ RNAs isolated from one clone that grew in the presence of G418 contained the two major classes of HBV-specific transcripts (3.5-kilobase pregenome and 2.1-kilobase mRNAs) in approximately equivalent amounts, which was reminiscent of the profiles of viral mRNAs from the livers of infected humans and chimpanzees.
| Original language | English |
|---|---|
| Pages (from-to) | 2921-2923 |
| Number of pages | 3 |
| Journal | Journal of Virology |
| Volume | 61 |
| Issue number | 9 |
| DOIs | |
| State | Published - 1987 |
Fingerprint
Dive into the research topics of 'Replicative intermediate of hepatitis B virus in transfected murine fibroblasts'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver