Repeated photon and C-ion irradiations in vivo have different impact on alteration of tumor characteristics

Katsutoshi Sato, Nobuhiro Nitta, Ichio Aoki, Takashi Imai, Takashi Shimokawa

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11 Scopus citations

Abstract

Precise characterization of tumor recurrence and regrowth after radiotherapy are important for prognostic understanding of the therapeutic effect. Here, we established a novel in vivo mouse model for evaluating the characteristics of regrown tumor after repeated photon and carbon ion (C-ion) irradiations. The results showed that tumor growth rate, lung metastasis, shortening of the survival of the tumor-bearing mice, and tumor microvessel formation were promoted 2- to 3-fold, and expression of angiogenic and metastatic genes increased 1.5- to 15-fold in regrown tumors after repeated photon irradiations, whereas repeated C-ion irradiations did not alter these characteristics. Interestingly, both repeated photon and C-ion irradiations did not generate radioresistance, which is generally acquired for in vitro treatment. Our results demonstrated that the repetition of photon, and not C-ion, irradiations in vivo alter the characteristics of the regrown tumor, making it more aggressive without acquisition of radioresistance.

Original languageEnglish
Article number1458
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - 1 Dec 2018
Externally publishedYes

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