Reparação vascular após implante de stents não-farmacológicos e farmacológicos em modelo experimental de fibroateroma de capa fina em coelhos

Translated title of the contribution: Vascular healing after bare metal and drug-eluting stents in an experimental rabbit model of thin cap fibroatheroma

Dario Echeverri, K. Raman Purushothaman, Pedro R. Moreno

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: The vascular healing response is an important factor in the development of restenosis and stent thrombosis. This study was designed to evaluate the vascular healing of bare metal stents (BMS) compared to everolimus (EES) and beta-estradiol (BES) eluting stents in a chronic atherosclerotic experimental animal model of thin cap fibroatheroma (TCFA). Methods: Sixteen New Zealand hypercholesterolemic rabbits followed for 4 years were studied. Six animals received BMS, 5 EES, and 5 BES (Guidant, Santa Clara, CA). One polymer stent per animal was also implanted. Results: Histologic analysis at 28 days of de-novo vs. BMS, EES, and BES stented TCFA showed polymer stents induced a higher fibrin and hemorrhage score. BES induced higher inflammation and fibrin scores and a lower endothelization score. EES induced higher inflammation, fibrin and hemorrhage scores. BES and EES induced similar healing scores. Percent collagen I areas were similar in all 4 types of stents. Percent collagen III areas were higher in BMS when compared to polymer and drugeluting stents. Conclusion: Drug-eluting stents are associated with low but increased inflammation, fibrin deposition and hemorrhage which seem to be related to the polymer's vascular effects.

Translated title of the contributionVascular healing after bare metal and drug-eluting stents in an experimental rabbit model of thin cap fibroatheroma
Original languagePortuguese
Pages (from-to)474-481
Number of pages8
JournalRevista Brasileira de Cardiologia Invasiva
Volume16
Issue number4
StatePublished - 2008
Externally publishedYes

Keywords

  • Atherosclerosis
  • Drug-eluting stents
  • Models, animal
  • Rabbits
  • Stents

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