REPAIR OF CYCLOBUTANE DIMERS AND (6–4) PHOTOPRODUCTS IN ICR 2A FROG CELLS

David L. Mitchell, Judith M. Clarkson, Chuck C.‐K Chao, Barry S. ROSENSTEIN

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Abstract— The removal of cyclobutane dimers and Pyr(6–4)Pyo photoproducts from the DNA of UV‐irradiated ICR 2A frog cells was determined by radioimmunoassay. In the absence of photoreactivat‐ing light, 15% of the cyclobutane dimers and 60% of the (6–4) photoproducts were removed 24 h post‐irradiation with 10 J m−2, Exposure to 30 kJ m−2 photoreactivating light resulted in removal of 80% of the cyclobutane dimers and an enhanced rate of repair of (6–4) photoproducts, resulting in a loss of 50% of these lesions in 3 h. The preferential removal of (6–4) photoproducts by excision repair resembles previously published data for mammalian cells.

Original languageEnglish
Pages (from-to)595-597
Number of pages3
JournalPhotochemistry and Photobiology
Volume43
Issue number5
DOIs
StatePublished - May 1986
Externally publishedYes

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