TY - JOUR
T1 - Renal Potassium Handling in Healthy and Sick Newborns
AU - Zhou, Hao
AU - Satlin, Lisa M.
N1 - Funding Information:
This work was supported in part by grants from the National Institutes of Health DK38470 and DK64104 (L.M.S.). H.Z. was supported by NIH T32 HD07537 training grant (L.M.S, PI).
PY - 2004/4
Y1 - 2004/4
N2 - Growing infants must maintain a state of positive K+ balance, a task accomplished, in large part, by the kidney. The distal nephron is uniquely adapted to retain total body K+ early in life. The magnitude and direction of net K+ transport in the cortical collecting duct (CCD), the segment responsible for the final renal regulation of K+ balance in the adult, reflect the balance of opposing fluxes of K+ secretion and K+ absorption. Evidence now indicates that the low capacity of the neonatal CCD for K+ secretion is due, at least in part, to a relative paucity of conducting K+ channels in the urinary membrane. A relative excess of K+ absorption in this nephron segment may further reduce net urinary K+ secretion. Under conditions prevailing in vivo, the balance of fluxes in the CCD likely contributes to the relative K+ retention characteristic of the neonatal kidney.
AB - Growing infants must maintain a state of positive K+ balance, a task accomplished, in large part, by the kidney. The distal nephron is uniquely adapted to retain total body K+ early in life. The magnitude and direction of net K+ transport in the cortical collecting duct (CCD), the segment responsible for the final renal regulation of K+ balance in the adult, reflect the balance of opposing fluxes of K+ secretion and K+ absorption. Evidence now indicates that the low capacity of the neonatal CCD for K+ secretion is due, at least in part, to a relative paucity of conducting K+ channels in the urinary membrane. A relative excess of K+ absorption in this nephron segment may further reduce net urinary K+ secretion. Under conditions prevailing in vivo, the balance of fluxes in the CCD likely contributes to the relative K+ retention characteristic of the neonatal kidney.
UR - http://www.scopus.com/inward/record.url?scp=2342520705&partnerID=8YFLogxK
U2 - 10.1053/j.semperi.2003.11.007
DO - 10.1053/j.semperi.2003.11.007
M3 - Article
C2 - 15200249
AN - SCOPUS:2342520705
SN - 0146-0005
VL - 28
SP - 103
EP - 111
JO - Seminars in Perinatology
JF - Seminars in Perinatology
IS - 2
ER -