Removal of propionic acid from fermentation broth by ion-exchange resins

Ting Hao, Qiang Li, Peng Wang, Yunshan Wang, Runyu Ma, Zhiguo Su

Research output: Contribution to journalArticlepeer-review

Abstract

The adsorption abilities of nine weakly basic anion exchange resins for propionic acid (PA) in vitamin B12 (VB12) fermentation broth have been evaluated. The static adsorption capacity on resin ZGA330 was found to be 44.9 mg/g dry beads at 12.6 g/L of PA. Dynamic state exchange trials, including the adsorption of glucose, amino acids and PA in the fermentation broth, were also carried out; these indicated that the adsorption of glucose and amino acids-the main nutrient components of the fermentation broth-was minimal. The dynamic adsorption capacity was 205.5 mg/g dry beads. By removal of propionic acid with ZGA330, the concentration of VB12 increased from 9.1 mg/L to 13.1 mg/L, an increase of 44%. This demonstrates that coupling of the fermentation process with separation and removal of propionic acid affords a significant improvement in the cell concentration and productivity of VB12.

Original languageEnglish
Pages (from-to)70-74
Number of pages5
JournalBeijing Huagong Daxue Xuebao (Ziran Kexueban)/Journal of Beijing University of Chemical Technology (Natural Science Edition)
Volume35
Issue number3
StatePublished - May 2008
Externally publishedYes

Keywords

  • Adsorption
  • Anion exchange resin
  • Propionic acid (PA)
  • Vitamin B

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