Remission of psoriasis with low dietary tryptophan.

H. Spiera; A. M. Lefkovits

doi:10.1016/s0140-6736(67)92970-4

Remission of psoriasis with low dietary tryptophan.

H. Spiera, A. M. Lefkovits

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Original language	English
Pages (from-to)	137-139
Number of pages	3
Journal	The Lancet
Volume	2
Issue number	7507
DOIs	https://doi.org/10.1016/s0140-6736(67)92970-4
State	Published - 15 Jul 1967

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10.1016/s0140-6736(67)92970-4

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@article{6e67b7adc2fb4ba18784b04a99627d55,

title = "Remission of psoriasis with low dietary tryptophan.",

author = "H. Spiera and Lefkovits, {A. M.}",

note = "Funding Information: tryptophan may eliminate the effect; or (2) psoriatic skin turns over at a far faster rate than does normal skin,5 and therefore may have a far greater requirement for essential aminoacids, including tryptophan-thus psoriatic skin may not be able to continue its rapid proliferation in the absence of adequate tryptophan. To test the second hypothesis, we plan to determine the effect of deprivation of other essential aminoacids on the course of psoriasis. The efficacy of antimetabolites such as aminopterin and methotrexate in the treatment of psoriasis is based on their ability to inhibit preferentially the growth of rapidly proliferating tissue. Deprivation of essential aminoacids may accomplish the same result as antimetabolites without attendant hazards. To date, none of the patients have suffered any ill-effects of the diet. None of the patients had been on the diet for longer than 2 months. Laboratory studies showed no impairment of renal, hepatic, cardiac, pulmonary, or erythropoietic function. Confirmation of this observation is necessary, and if verified provides a possible method of therapy for this common disease, and a basis for new areas of investigation. We thank the staff of the Clinical Research Center of the Mount Sinai Hospital, and most particularly Dr. Irwin Oreskes for the aminoacid chromatography. The work was supported by U.S. Public Health Service research grants AM 07726 and FR 71. HARRY SPIERA M.D. New York ALBERT M. LEFKOVITS M.D. New York Medical College.",

year = "1967",

month = jul,

day = "15",

doi = "10.1016/s0140-6736(67)92970-4",

language = "English",

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pages = "137--139",

journal = "The Lancet",

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}

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T1 - Remission of psoriasis with low dietary tryptophan.

AU - Spiera, H.

AU - Lefkovits, A. M.

N1 - Funding Information: tryptophan may eliminate the effect; or (2) psoriatic skin turns over at a far faster rate than does normal skin,5 and therefore may have a far greater requirement for essential aminoacids, including tryptophan-thus psoriatic skin may not be able to continue its rapid proliferation in the absence of adequate tryptophan. To test the second hypothesis, we plan to determine the effect of deprivation of other essential aminoacids on the course of psoriasis. The efficacy of antimetabolites such as aminopterin and methotrexate in the treatment of psoriasis is based on their ability to inhibit preferentially the growth of rapidly proliferating tissue. Deprivation of essential aminoacids may accomplish the same result as antimetabolites without attendant hazards. To date, none of the patients have suffered any ill-effects of the diet. None of the patients had been on the diet for longer than 2 months. Laboratory studies showed no impairment of renal, hepatic, cardiac, pulmonary, or erythropoietic function. Confirmation of this observation is necessary, and if verified provides a possible method of therapy for this common disease, and a basis for new areas of investigation. We thank the staff of the Clinical Research Center of the Mount Sinai Hospital, and most particularly Dr. Irwin Oreskes for the aminoacid chromatography. The work was supported by U.S. Public Health Service research grants AM 07726 and FR 71. HARRY SPIERA M.D. New York ALBERT M. LEFKOVITS M.D. New York Medical College.

PY - 1967/7/15

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