Relief of pain of fabry’s disease by diphenylhydantoin

Lawrence A. Lockman, Donald B. Hunninghake, William Krivit, Robert J. Desnick

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Eight patients with clinically and biochemically diagnosed Fabry’s disease and chronic acroparesthesias were treated with diphenylhydantoin, aspirin or multivitamins in a double-blind crossover controlled study. Plasma diphenylhydantoin concentrations of more than 4 mcg per milliliter were effective in eliminating the pain associated with Fabry’s disease.

Original languageEnglish
Pages (from-to)871-875
Number of pages5
Issue number8
StatePublished - Aug 1973
Externally publishedYes


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