Relevance of ploidy related parameters for prognosis in malignant fibrous histiocytomas

Ulrich Brinck; Monika Korabiowska; Nadine Buschmann; Jerzy Stachura; Ilka Ruschenburg; Carlos Cordon-Cardo; Alfred Schauer

Relevance of ploidy related parameters for prognosis in malignant fibrous histiocytomas

Ulrich Brinck, Monika Korabiowska, Nadine Buschmann, Jerzy Stachura, Ilka Ruschenburg, Carlos Cordon-Cardo, Alfred Schauer

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Ploidy associated parameters were determined in 161 malignant fibrous histiocytomas (MFH) by DNA image cytometry. The rate of euploid cases in MFH with histopathological grade I was 42%, grade II 16% and grade III 6%. Univariate analyses showed that cases with a low percentage of diploid cells (< 40%) and cases with high rates of aneuploid cells between 4c and 8c (> 9%), octaploid cells (> 0%) and 16-ploid cells (> 0%), high 2.5c (> 60%) and 5c (> 16%) exceeding rates and cases with high DNA indices of the first (> 1.08) and the second (> 3.78) peak had significantly reduced survival rates. Multivariate analyses with Cox regression demonstrated that in addition to grade, only the percentage of aneuploid cells between 4c and 8c, the 5c exceeding rate and the DNA index of the first peak had independent prognostic impact. It was concluded that besides ploidy status and grading, ploidy associated parameters are suited for prediction of survival in MFH.

Original language	English
Pages (from-to)	5211-5216
Number of pages	6
Journal	Anticancer Research
Volume	19
Issue number	6 B
State	Published - Nov 1999
Externally published	Yes

Keywords

CAS200
MFH
Ploidy

Cite this

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title = "Relevance of ploidy related parameters for prognosis in malignant fibrous histiocytomas",

abstract = "Ploidy associated parameters were determined in 161 malignant fibrous histiocytomas (MFH) by DNA image cytometry. The rate of euploid cases in MFH with histopathological grade I was 42%, grade II 16% and grade III 6%. Univariate analyses showed that cases with a low percentage of diploid cells (< 40%) and cases with high rates of aneuploid cells between 4c and 8c (> 9%), octaploid cells (> 0%) and 16-ploid cells (> 0%), high 2.5c (> 60%) and 5c (> 16%) exceeding rates and cases with high DNA indices of the first (> 1.08) and the second (> 3.78) peak had significantly reduced survival rates. Multivariate analyses with Cox regression demonstrated that in addition to grade, only the percentage of aneuploid cells between 4c and 8c, the 5c exceeding rate and the DNA index of the first peak had independent prognostic impact. It was concluded that besides ploidy status and grading, ploidy associated parameters are suited for prediction of survival in MFH.",

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author = "Ulrich Brinck and Monika Korabiowska and Nadine Buschmann and Jerzy Stachura and Ilka Ruschenburg and Carlos Cordon-Cardo and Alfred Schauer",

year = "1999",

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language = "English",

volume = "19",

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journal = "Anticancer Research",

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TY - JOUR

T1 - Relevance of ploidy related parameters for prognosis in malignant fibrous histiocytomas

AU - Brinck, Ulrich

AU - Korabiowska, Monika

AU - Buschmann, Nadine

AU - Stachura, Jerzy

AU - Ruschenburg, Ilka

AU - Cordon-Cardo, Carlos

AU - Schauer, Alfred

PY - 1999/11

Y1 - 1999/11

N2 - Ploidy associated parameters were determined in 161 malignant fibrous histiocytomas (MFH) by DNA image cytometry. The rate of euploid cases in MFH with histopathological grade I was 42%, grade II 16% and grade III 6%. Univariate analyses showed that cases with a low percentage of diploid cells (< 40%) and cases with high rates of aneuploid cells between 4c and 8c (> 9%), octaploid cells (> 0%) and 16-ploid cells (> 0%), high 2.5c (> 60%) and 5c (> 16%) exceeding rates and cases with high DNA indices of the first (> 1.08) and the second (> 3.78) peak had significantly reduced survival rates. Multivariate analyses with Cox regression demonstrated that in addition to grade, only the percentage of aneuploid cells between 4c and 8c, the 5c exceeding rate and the DNA index of the first peak had independent prognostic impact. It was concluded that besides ploidy status and grading, ploidy associated parameters are suited for prediction of survival in MFH.

AB - Ploidy associated parameters were determined in 161 malignant fibrous histiocytomas (MFH) by DNA image cytometry. The rate of euploid cases in MFH with histopathological grade I was 42%, grade II 16% and grade III 6%. Univariate analyses showed that cases with a low percentage of diploid cells (< 40%) and cases with high rates of aneuploid cells between 4c and 8c (> 9%), octaploid cells (> 0%) and 16-ploid cells (> 0%), high 2.5c (> 60%) and 5c (> 16%) exceeding rates and cases with high DNA indices of the first (> 1.08) and the second (> 3.78) peak had significantly reduced survival rates. Multivariate analyses with Cox regression demonstrated that in addition to grade, only the percentage of aneuploid cells between 4c and 8c, the 5c exceeding rate and the DNA index of the first peak had independent prognostic impact. It was concluded that besides ploidy status and grading, ploidy associated parameters are suited for prediction of survival in MFH.

KW - CAS200

KW - MFH

KW - Ploidy

UR - http://www.scopus.com/inward/record.url?scp=0033367226&partnerID=8YFLogxK

M3 - Article

C2 - 10697537

AN - SCOPUS:0033367226

SN - 0250-7005

VL - 19

SP - 5211

EP - 5216

JO - Anticancer Research

JF - Anticancer Research

IS - 6 B

ER -

Relevance of ploidy related parameters for prognosis in malignant fibrous histiocytomas

Abstract

Keywords

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