Release of xenotropic type C RNA in response to lipopolysaccharide: activity of lipid A portion upon B lymphocytes

M. Phillips; J. R. Stephenson; J. S. Greenberger; P. E. Lane; S. A. Aaronson

Release of xenotropic type C RNA in response to lipopolysaccharide: activity of lipid A portion upon B lymphocytes

M. Phillips, J. R. Stephenson, J. S. Greenberger, P. E. Lane, S. A. Aaronson

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25 Scopus citations

Abstract

The present studies demonstrate that lipopolysaccharide (LPS) causes the release of endogenous xenotropic type C RNA virus from BALB/c spleen cells. The evidence suggests that virus release is stimulated by the lipid A portion of LPS and primarily involves an action of LPS on B lymphocytes. LPS had little or no effect on virus release by T lymphocytes, macrophages, or fibroblasts. These results indicate that the differentiated state of the cells plays an important role in the regulation of endogenous virus release.

Original language	English
Pages (from-to)	1123-1128
Number of pages	6
Journal	Journal of Immunology
Volume	116
Issue number	4
State	Published - 1976

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title = "Release of xenotropic type C RNA in response to lipopolysaccharide: activity of lipid A portion upon B lymphocytes",

abstract = "The present studies demonstrate that lipopolysaccharide (LPS) causes the release of endogenous xenotropic type C RNA virus from BALB/c spleen cells. The evidence suggests that virus release is stimulated by the lipid A portion of LPS and primarily involves an action of LPS on B lymphocytes. LPS had little or no effect on virus release by T lymphocytes, macrophages, or fibroblasts. These results indicate that the differentiated state of the cells plays an important role in the regulation of endogenous virus release.",

author = "M. Phillips and Stephenson, {J. R.} and Greenberger, {J. S.} and Lane, {P. E.} and Aaronson, {S. A.}",

year = "1976",

language = "English",

volume = "116",

pages = "1123--1128",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

number = "4",

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T1 - Release of xenotropic type C RNA in response to lipopolysaccharide

T2 - activity of lipid A portion upon B lymphocytes

AU - Phillips, M.

AU - Stephenson, J. R.

AU - Greenberger, J. S.

AU - Lane, P. E.

AU - Aaronson, S. A.

PY - 1976

Y1 - 1976

N2 - The present studies demonstrate that lipopolysaccharide (LPS) causes the release of endogenous xenotropic type C RNA virus from BALB/c spleen cells. The evidence suggests that virus release is stimulated by the lipid A portion of LPS and primarily involves an action of LPS on B lymphocytes. LPS had little or no effect on virus release by T lymphocytes, macrophages, or fibroblasts. These results indicate that the differentiated state of the cells plays an important role in the regulation of endogenous virus release.

AB - The present studies demonstrate that lipopolysaccharide (LPS) causes the release of endogenous xenotropic type C RNA virus from BALB/c spleen cells. The evidence suggests that virus release is stimulated by the lipid A portion of LPS and primarily involves an action of LPS on B lymphocytes. LPS had little or no effect on virus release by T lymphocytes, macrophages, or fibroblasts. These results indicate that the differentiated state of the cells plays an important role in the regulation of endogenous virus release.

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M3 - Article

C2 - 176273

AN - SCOPUS:0017226853

SN - 0022-1767

VL - 116

SP - 1123

EP - 1128

JO - Journal of Immunology

JF - Journal of Immunology

IS - 4

ER -

Release of xenotropic type C RNA in response to lipopolysaccharide: activity of lipid A portion upon B lymphocytes

Abstract

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