Relationships between brain activation and brain structure in normally developing children

Lisa H. Lu; Mirella Dapretto; Elizabeth D. O'Hare; Eric Kan; Sarah T. McCourt; Paul M. Thompson; Arthur W. Toga; Susan Y. Bookheimer; Elizabeth R. Sowell

doi:10.1093/cercor/bhp011

Relationships between brain activation and brain structure in normally developing children

Lisa H. Lu, Mirella Dapretto, Elizabeth D. O'Hare, Eric Kan, Sarah T. McCourt, Paul M. Thompson, Arthur W. Toga, Susan Y. Bookheimer, Elizabeth R. Sowell

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Dynamic changes in brain structure, activation, and cognitive abilities co-occur during development, but little is known about how changes in brain structure relate to changes in cognitive function or brain activity. By using cortical pattern matching techniques to correlate cortical gray matter thickness and functional brain activity over the entire brain surface in 24 typically developing children, we integrated structural and functional magnetic resonance imaging data with cognitive test scores to identify correlates of mature performance during orthographic processing. Fast-naming individuals activated the right fronto-parietal attention network in response to novel fonts more than slow-naming individuals, and increased activation of this network was correlated with more mature brain morphology in the same fronto-parietal region. These relationships remained even after effects of age or general cognitive ability were statistically controlled. These results localized cortical regions where mature morphology corresponds to mature patterns of activation, and may suggest a role for experience in mediating brain structure-activation relationships.

Original language	English
Pages (from-to)	2595-2604
Number of pages	10
Journal	Cerebral Cortex
Volume	19
Issue number	11
DOIs	https://doi.org/10.1093/cercor/bhp011
State	Published - Nov 2009
Externally published	Yes

Keywords

Attention
FMRI
Imaging
Language
Morphometry

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title = "Relationships between brain activation and brain structure in normally developing children",

abstract = "Dynamic changes in brain structure, activation, and cognitive abilities co-occur during development, but little is known about how changes in brain structure relate to changes in cognitive function or brain activity. By using cortical pattern matching techniques to correlate cortical gray matter thickness and functional brain activity over the entire brain surface in 24 typically developing children, we integrated structural and functional magnetic resonance imaging data with cognitive test scores to identify correlates of mature performance during orthographic processing. Fast-naming individuals activated the right fronto-parietal attention network in response to novel fonts more than slow-naming individuals, and increased activation of this network was correlated with more mature brain morphology in the same fronto-parietal region. These relationships remained even after effects of age or general cognitive ability were statistically controlled. These results localized cortical regions where mature morphology corresponds to mature patterns of activation, and may suggest a role for experience in mediating brain structure-activation relationships.",

keywords = "Attention, FMRI, Imaging, Language, Morphometry",

author = "Lu, {Lisa H.} and Mirella Dapretto and O'Hare, {Elizabeth D.} and Eric Kan and McCourt, {Sarah T.} and Thompson, {Paul M.} and Toga, {Arthur W.} and Bookheimer, {Susan Y.} and Sowell, {Elizabeth R.}",

note = "Funding Information: National Institute of Drug Abuse Grants (R21 DA15878 and RO1 DA017831) awarded to E.R.S.; National Institute of Health (NIH)/National Center for Research Resources grant (P41 RR013642); National Institute of Neurological Disorders and Stroke grant (NS3753) awarded to A.W.T; grants (AG016570, LM05639, EB01651, and RR019771) supported P.M.T.; and NIH Roadmap for Medical Research grant (U54 RR021813 entitled Center for Computational Biology).",

year = "2009",

month = nov,

doi = "10.1093/cercor/bhp011",

language = "English",

volume = "19",

pages = "2595--2604",

journal = "Cerebral Cortex",

issn = "1047-3211",

publisher = "Oxford University Press",

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AU - Lu, Lisa H.

AU - Dapretto, Mirella

AU - O'Hare, Elizabeth D.

AU - Kan, Eric

AU - McCourt, Sarah T.

AU - Thompson, Paul M.

AU - Toga, Arthur W.

AU - Bookheimer, Susan Y.

AU - Sowell, Elizabeth R.

N1 - Funding Information: National Institute of Drug Abuse Grants (R21 DA15878 and RO1 DA017831) awarded to E.R.S.; National Institute of Health (NIH)/National Center for Research Resources grant (P41 RR013642); National Institute of Neurological Disorders and Stroke grant (NS3753) awarded to A.W.T; grants (AG016570, LM05639, EB01651, and RR019771) supported P.M.T.; and NIH Roadmap for Medical Research grant (U54 RR021813 entitled Center for Computational Biology).

PY - 2009/11

Y1 - 2009/11

N2 - Dynamic changes in brain structure, activation, and cognitive abilities co-occur during development, but little is known about how changes in brain structure relate to changes in cognitive function or brain activity. By using cortical pattern matching techniques to correlate cortical gray matter thickness and functional brain activity over the entire brain surface in 24 typically developing children, we integrated structural and functional magnetic resonance imaging data with cognitive test scores to identify correlates of mature performance during orthographic processing. Fast-naming individuals activated the right fronto-parietal attention network in response to novel fonts more than slow-naming individuals, and increased activation of this network was correlated with more mature brain morphology in the same fronto-parietal region. These relationships remained even after effects of age or general cognitive ability were statistically controlled. These results localized cortical regions where mature morphology corresponds to mature patterns of activation, and may suggest a role for experience in mediating brain structure-activation relationships.

AB - Dynamic changes in brain structure, activation, and cognitive abilities co-occur during development, but little is known about how changes in brain structure relate to changes in cognitive function or brain activity. By using cortical pattern matching techniques to correlate cortical gray matter thickness and functional brain activity over the entire brain surface in 24 typically developing children, we integrated structural and functional magnetic resonance imaging data with cognitive test scores to identify correlates of mature performance during orthographic processing. Fast-naming individuals activated the right fronto-parietal attention network in response to novel fonts more than slow-naming individuals, and increased activation of this network was correlated with more mature brain morphology in the same fronto-parietal region. These relationships remained even after effects of age or general cognitive ability were statistically controlled. These results localized cortical regions where mature morphology corresponds to mature patterns of activation, and may suggest a role for experience in mediating brain structure-activation relationships.

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Relationships between brain activation and brain structure in normally developing children

Abstract

Keywords

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