TY - JOUR
T1 - Relationship of thallium-201 myocardial perfusion pattern to regional and global left ventricular function with exercise
AU - Kirshenbaum, Howard D.
AU - Okada, Robert D.
AU - Boucher, Charles A.
AU - Kushner, Fredrick G.
AU - Strauss, H. William
AU - Pohost, Gerald M.
N1 - Funding Information:
From the Division of Cardiovascular Medicine and Department of Medicine, University of Massachusetts Medical Center and Medical School, Worcester, and the Cardiac Unit, Department of Medicine and Department of Nuclear Medicine, Massachusetts General Hospital and Harvard Medical School. Supported in part by USPHS Grant HL21751 and by Training F32-HL05837-1. Received for publication Oct. 9, 1980; accepted Feb. 21, 1981. Reprint requests: Howard D. Kiisbenbaum, M.D., Division of Cardiovascular Medicine, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01605.
PY - 1981/6
Y1 - 1981/6
N2 - Thallium-201 redistribution pattern after exercise was related to rest and exercise left ventricular regional and global function, measured by radionuclide ventriculography, in 61 patients, 50 with coronary artery disease (CAD). Sixteen patients had exclusively transient thallium defects, suggesting ischemia: in this group, mean left ventricular ejection fraction (LVEF) was 65% at rest, falling to 58% during exercise (p < 0.01). Eight patients had exclusively persistent thallium defects, suggesting scar: LVEF was unchanged during exercise, 58% to 59%. LVEF increased during exercise in the 17 patients without exercise thallium defects, seven with CAD: 66% to 73% (p < 0.05). Individual LV wall segments which exhibited translent or persistent thallium defects contracted abnormally both at rest and during exercise as compared to LV segments without exercise thallium defects. We conclude that: (1) only transient thallium defects rellably predict worsening left ventricular global function during exercise; (2) both transient and persistent thallium defects can be associlated with resting dyssynergy; and (3) in some CAD patients, apparent hypoperfusion does not necessarlly predict left ventricular dysfunction during exercise.
AB - Thallium-201 redistribution pattern after exercise was related to rest and exercise left ventricular regional and global function, measured by radionuclide ventriculography, in 61 patients, 50 with coronary artery disease (CAD). Sixteen patients had exclusively transient thallium defects, suggesting ischemia: in this group, mean left ventricular ejection fraction (LVEF) was 65% at rest, falling to 58% during exercise (p < 0.01). Eight patients had exclusively persistent thallium defects, suggesting scar: LVEF was unchanged during exercise, 58% to 59%. LVEF increased during exercise in the 17 patients without exercise thallium defects, seven with CAD: 66% to 73% (p < 0.05). Individual LV wall segments which exhibited translent or persistent thallium defects contracted abnormally both at rest and during exercise as compared to LV segments without exercise thallium defects. We conclude that: (1) only transient thallium defects rellably predict worsening left ventricular global function during exercise; (2) both transient and persistent thallium defects can be associlated with resting dyssynergy; and (3) in some CAD patients, apparent hypoperfusion does not necessarlly predict left ventricular dysfunction during exercise.
UR - http://www.scopus.com/inward/record.url?scp=0019509149&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(81)90608-6
DO - 10.1016/0002-8703(81)90608-6
M3 - Article
C2 - 7234650
AN - SCOPUS:0019509149
SN - 0002-8703
VL - 101
SP - 734
EP - 739
JO - American Heart Journal
JF - American Heart Journal
IS - 6
ER -