TY - JOUR
T1 - Relationship of patent ductus arteriosus management with neonatal AKI
AU - on behalf of the Neonatal Kidney Collaborative
AU - Guillet, Ronnie
AU - Selewski, David T.
AU - Griffin, Russell
AU - Rastogi, Shantanu
AU - Askenazi, David J.
AU - D’Angio, Carl T.
AU - Askenazi, David
AU - Ambalavanan, N.
AU - Griffin, Russell
AU - Goldstein, Stuart
AU - Nathan, Amy
AU - Greenberg, James
AU - Kent, Alison
AU - Fletcher, Jeffrey
AU - Sethna, Farah
AU - Soranno, Danielle
AU - Gien, Jason
AU - Gist, Katja
AU - Fuloria, Mamta
AU - Reidy, Kim
AU - Kastel, Frederick
AU - Uy, Natalie
AU - Revenis, Mary
AU - Perrazo, Sofia
AU - Rastogi, Shantanu
AU - Schwartz, George
AU - D’Angio, Carl T.
AU - Guillet, Ronnie
AU - Rademacher, Erin
AU - El Samra, Ahmed
AU - Mian, Ayesa
AU - Kupferman, Juan
AU - Bhutada, Alok
AU - Zappitelli, Michael
AU - Wintermark, Pia
AU - Wazir, Sanjay
AU - Sethi, Sidharth
AU - Dubey, Sandeep
AU - Mhanna, Maroun
AU - Kumar, Deepak
AU - Raina, Rupesh
AU - Ingraham, Susan
AU - Nada, Arwa
AU - Bonachea, Elizabeth
AU - Fine, Richard
AU - Woroniecki, Robert
AU - Sridhar, Shanthy
AU - Ariken, Ayse
AU - Rhee, Christopher
AU - Milner, Lawrence
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2021/6
Y1 - 2021/6
N2 - Objective: Investigate relationship between management of patent ductus arteriosus (PDA) and acute kidney injury (AKI) in very low birthweight neonates. Study Design: Retrospective cohort study of neonates, <1500 g, admitted to 24 NICUs, 1/1/14 – 3/31/14. AKI diagnosed using the neonatal modified KDIGO definition; diagnosis and treatment of PDA extracted from the medical record. Demographics, clinical characteristics, and AKI stage compared using chi-square and analysis of variance. A general estimating equation logistic regression used to estimate adjusted odds ratios. Results: Of 526 neonates with sufficient data to diagnose AKI, 157 (30%) had PDA (61 conservative management, 62 pharmacologic treatment only, 34 surgical ligation). In analyses adjusted for sex, birthweight, gestational age, caffeine, nephrotoxin exposure, vasopressor and mechanical ventilation use, with conservative management as reference, there were no differences among treatment cohorts in the odds of AKI. Conclusion: The underlying physiology of PDA, not management strategy, may determine the likelihood of AKI in neonates <1500 g.
AB - Objective: Investigate relationship between management of patent ductus arteriosus (PDA) and acute kidney injury (AKI) in very low birthweight neonates. Study Design: Retrospective cohort study of neonates, <1500 g, admitted to 24 NICUs, 1/1/14 – 3/31/14. AKI diagnosed using the neonatal modified KDIGO definition; diagnosis and treatment of PDA extracted from the medical record. Demographics, clinical characteristics, and AKI stage compared using chi-square and analysis of variance. A general estimating equation logistic regression used to estimate adjusted odds ratios. Results: Of 526 neonates with sufficient data to diagnose AKI, 157 (30%) had PDA (61 conservative management, 62 pharmacologic treatment only, 34 surgical ligation). In analyses adjusted for sex, birthweight, gestational age, caffeine, nephrotoxin exposure, vasopressor and mechanical ventilation use, with conservative management as reference, there were no differences among treatment cohorts in the odds of AKI. Conclusion: The underlying physiology of PDA, not management strategy, may determine the likelihood of AKI in neonates <1500 g.
UR - http://www.scopus.com/inward/record.url?scp=85104640687&partnerID=8YFLogxK
U2 - 10.1038/s41372-021-01054-1
DO - 10.1038/s41372-021-01054-1
M3 - Article
C2 - 33875795
AN - SCOPUS:85104640687
SN - 0743-8346
VL - 41
SP - 1441
EP - 1447
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 6
ER -