Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography

Ryo Nakazato, Heidi Gransar, Daniel S. Berman, Victor Y. Cheng, Fay Y. Lin, Stephan Achenbach, Mouaz Al-Mallah, Matthew J. Budoff, Filippo Cademartiri, Tracy Q. Callister, Hyuk Jae Chang, Kavitha Chinnaiyan, Benjamin J.W. Chow, Augustin Delago, Martin Hadamitzky, Joerg Hausleiter, Philipp Kaufmann, Erica Maffei, Gilbert Raff, Leslee J. ShawTodd C. Villines, Allison Dunning, Ricardo C. Cury, Gudrun Feuchtner, Yong Jin Kim, Jonathon Leipsic, James K. Min

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background: The association between lipoprotein levels and coronary plaque composition is not well understood. Objective: The aim of this prospective international multicenter study of statin-naive individuals was to evaluate the association of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC) to coronary plaque composition by coronary computed tomographic angiography (CTA). Methods: We studied 4575 individuals without known coronary artery disease not taking statin medications who underwent coronary CTA. Comparisons were made between those with high versus low LDL, HDL, TC, and non-HDL. We assessed the relationship of lipoproteins and plaques of specific composition (noncalcified [NCP], partially calcified [PCP], or calcified [CP] plaque). Results: Mean age was 57 ± 11 years (55% men). In univariable analyses, high LDL, low HDL, high TC, and high non-HDL were each associated with increased prevalence of NCPs, PCPs, and CPs (P < 0.05 for all). In multivariable analyses, high non-HDL was associated with the presence of NCP (odds ratio, 1.47; 95% CI, 1.22-1.78: P < 0.001). In the further subanalysis, a weak relationship between the highest group of non HDL (≥190 mg/dL) and the presence of CP was also noted (odds ratio, 1.33; 95% CI, 1.01-1.76; P = 0.04). Further, high non-HDL was associated with increasing numbers of segments with NCP (β coefficient, 0.043; 95% CI, 0.021-0.065; P < 0.001) but not segments with PCP or CP. Conclusion: NCP presence and extent are associated with high non-HDL. These results suggest a relationship between lipid profile and plaque composition.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalJournal of Cardiovascular Computed Tomography
Issue number2
StatePublished - Mar 2013
Externally publishedYes


  • Coronary CTA
  • Coronary artery disease
  • Lipid profile
  • Plaque composition
  • Serum lipoproteins


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