TY - JOUR
T1 - Relationship of inferior olive-climbing fibers to p,p′-DDT-induced myoclonus in rats
AU - Chung Hwang, E.
AU - Plaitakis, A.
AU - Magnussen, I.
AU - Van Woert, M. H.
N1 - Funding Information:
This work was supportedb y USPHS Fellowship NS 05802 (E.C.H.), Merck InternationaFle llowship( I.M.), USPHS Grant NS 12341 and the Clinical Center for Researcho n Parkinson'sa nd Allied DiseasesG rant NS 71631.
PY - 1981/6/12
Y1 - 1981/6/12
N2 - The effects of 3-acetylpyridine (3-AP), which destroys the inferior olive, and harmaline, which stimulates inferior olive-climbing fiber activity, on DDT-induced myoclonus, were studied in rats. 3-AP shortened and harmaline delayed the time of onset of myoclonus after intragastric administration of DDT. 3-AP also counteracted the antimyoclonic action of l-5-hydroxytryptophan plus chlorimipramine, clonazepam and phenoxybenzamine in this animal model. The results suggest that these antimyoclonic agents require an intact olivocerebellar pathway for their action.
AB - The effects of 3-acetylpyridine (3-AP), which destroys the inferior olive, and harmaline, which stimulates inferior olive-climbing fiber activity, on DDT-induced myoclonus, were studied in rats. 3-AP shortened and harmaline delayed the time of onset of myoclonus after intragastric administration of DDT. 3-AP also counteracted the antimyoclonic action of l-5-hydroxytryptophan plus chlorimipramine, clonazepam and phenoxybenzamine in this animal model. The results suggest that these antimyoclonic agents require an intact olivocerebellar pathway for their action.
UR - http://www.scopus.com/inward/record.url?scp=0019794824&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(81)90367-0
DO - 10.1016/0304-3940(81)90367-0
M3 - Article
C2 - 7266934
AN - SCOPUS:0019794824
SN - 0304-3940
VL - 24
SP - 103
EP - 108
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -