@article{4e4c554bd440454db9527645e8c29805,
title = "Relationship of estrogen synthesis capacity in the brain with obesity and self-control in men and women",
abstract = "Gonadal hormones are linked to mechanisms that govern appetitive behavior and its suppression. Estrogens are synthesized from androgens by the enzyme aromatase, highly expressed in the ovaries of reproductive-aged women and in the brains of men and women of all ages. We measured aromatase availability in the amygdala using positron emission tomography (PET) with the aromatase inhibitor [11C]vorozole in a sample of 43 adult, normal-weight, overweight, or obese men and women. A subsample of 27 also completed personality measures to examine the relationship between aromatase and personality traits related to self-regulation and inhibitory control. Results indicated that aromatase availability in the amygdala was negatively associated with body mass index (BMI) (in kilograms per square meter) and positively correlated with scores of the personality trait constraint independent of sex or age. Individual variations in the brain{\textquoteright}s capacity to synthesize estrogen may influence the risk of obesity and self-control in men and women.",
keywords = "Amygdala, Aromatase, Estrogen, Obesity, PET imaging",
author = "Anat Biegon and Nelly Alia-Klein and Alexoff, {David L.} and Fowler, {Joanna S.} and Kim, {Sung Won} and Jean Logan and Deborah Pareto and Rebecca Preston-Campbell and Wang, {Gene Jack} and Tom Hildebrandt",
note = "Funding Information: ACKNOWLEDGMENTS. This study was carried out at Brookhaven National Laboratory under Contract DE-AC02-98CH10886 with the US Department of Energy and with infrastructure support from its Office of Biological and Environmental Research. The study was also supported in part by NIH Grant 1R21EB012707 and Brookhaven National Laboratory/Laboratory-Directed Research and Development funds (A.B., principal investigator). We also thank the National Institute of Alcohol Abuse and Alcoholism Intramural Program for salary support for S.W.K. We acknowledge and greatly appreciate the excellent work of Mike Schueller, Don Warner, David Schlyer, Millard Jayne, Pauline Carter, Barbara Hubbard, Payton King, Lisa Muench, Colleen Shea, and Youwen Xu. We are also grateful to the individuals who volunteered for these studies. Publisher Copyright: {\textcopyright} 2020 National Academy of Sciences. All rights reserved.",
year = "2020",
month = sep,
day = "15",
doi = "10.1073/pnas.2006117117",
language = "English",
volume = "117",
pages = "22962--22966",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "37",
}