Relationship of endogenous levels of sex hormones to cognition and depression in frail, elderly women

Brenda Breuer; Charles Martucci; Sylvan Wallenstein; Antonios Likourezos; Leslie S. Libow; Ann Peterson; Barnett Zumoff

doi:10.1097/00019442-200205000-00011

Relationship of endogenous levels of sex hormones to cognition and depression in frail, elderly women

Brenda Breuer
, Charles Martucci
, Sylvan Wallenstein
, Antonios Likourezos
, Leslie S. Libow
, Ann Peterson
, Barnett Zumoff

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Neuropsychological evaluations and sex hormone assays for 188 elderly, female nursing home residents (mean age: 87.8 years; standard deviation: 7.0 years) revealed inverse relationships for dehydroepiandrosterone (DHEA) blood levels and cognition scores based on the Mini-Mental State Exam and the Test for Severe Impairment, as well as for scores of the Immediate Recall, Copy, and Recognition tests of the Visual Reproduction subtest of the Wechsler Memory Scale-Revised (WMS-R; VR). A positive correlation between estrone and depression approached significance, as did the inverse relationships between the Recognition scores of the WMS-R; VR with androstenedione. These results and findings of others suggest that sex hormone actions in elderly women may differ from those in younger populations. A possible stress-related mechanism is also posited.

Original language	English
Pages (from-to)	311-320
Number of pages	10
Journal	American Journal of Geriatric Psychiatry
Volume	10
Issue number	3
DOIs	https://doi.org/10.1097/00019442-200205000-00011
State	Published - 2002
Externally published	Yes

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10.1097/00019442-200205000-00011

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title = "Relationship of endogenous levels of sex hormones to cognition and depression in frail, elderly women",

abstract = "Neuropsychological evaluations and sex hormone assays for 188 elderly, female nursing home residents (mean age: 87.8 years; standard deviation: 7.0 years) revealed inverse relationships for dehydroepiandrosterone (DHEA) blood levels and cognition scores based on the Mini-Mental State Exam and the Test for Severe Impairment, as well as for scores of the Immediate Recall, Copy, and Recognition tests of the Visual Reproduction subtest of the Wechsler Memory Scale-Revised (WMS-R; VR). A positive correlation between estrone and depression approached significance, as did the inverse relationships between the Recognition scores of the WMS-R; VR with androstenedione. These results and findings of others suggest that sex hormone actions in elderly women may differ from those in younger populations. A possible stress-related mechanism is also posited.",

author = "Brenda Breuer and Charles Martucci and Sylvan Wallenstein and Antonios Likourezos and Libow, \{Leslie S.\} and Ann Peterson and Barnett Zumoff",

note = "Funding Information: This research was supported by a grant to the Jewish Home and Hospital from the New York State Department of Health, Office of Continuing Care. ",

year = "2002",

doi = "10.1097/00019442-200205000-00011",

language = "English",

volume = "10",

pages = "311--320",

journal = "American Journal of Geriatric Psychiatry",

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TY - JOUR

T1 - Relationship of endogenous levels of sex hormones to cognition and depression in frail, elderly women

AU - Breuer, Brenda

AU - Martucci, Charles

AU - Wallenstein, Sylvan

AU - Likourezos, Antonios

AU - Libow, Leslie S.

AU - Peterson, Ann

AU - Zumoff, Barnett

N1 - Funding Information: This research was supported by a grant to the Jewish Home and Hospital from the New York State Department of Health, Office of Continuing Care.

PY - 2002

Y1 - 2002

N2 - Neuropsychological evaluations and sex hormone assays for 188 elderly, female nursing home residents (mean age: 87.8 years; standard deviation: 7.0 years) revealed inverse relationships for dehydroepiandrosterone (DHEA) blood levels and cognition scores based on the Mini-Mental State Exam and the Test for Severe Impairment, as well as for scores of the Immediate Recall, Copy, and Recognition tests of the Visual Reproduction subtest of the Wechsler Memory Scale-Revised (WMS-R; VR). A positive correlation between estrone and depression approached significance, as did the inverse relationships between the Recognition scores of the WMS-R; VR with androstenedione. These results and findings of others suggest that sex hormone actions in elderly women may differ from those in younger populations. A possible stress-related mechanism is also posited.

AB - Neuropsychological evaluations and sex hormone assays for 188 elderly, female nursing home residents (mean age: 87.8 years; standard deviation: 7.0 years) revealed inverse relationships for dehydroepiandrosterone (DHEA) blood levels and cognition scores based on the Mini-Mental State Exam and the Test for Severe Impairment, as well as for scores of the Immediate Recall, Copy, and Recognition tests of the Visual Reproduction subtest of the Wechsler Memory Scale-Revised (WMS-R; VR). A positive correlation between estrone and depression approached significance, as did the inverse relationships between the Recognition scores of the WMS-R; VR with androstenedione. These results and findings of others suggest that sex hormone actions in elderly women may differ from those in younger populations. A possible stress-related mechanism is also posited.

UR - https://www.scopus.com/pages/publications/0036093982

U2 - 10.1097/00019442-200205000-00011

DO - 10.1097/00019442-200205000-00011

M3 - Article

AN - SCOPUS:0036093982

SN - 1064-7481

VL - 10

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EP - 320

JO - American Journal of Geriatric Psychiatry

JF - American Journal of Geriatric Psychiatry

IS - 3

ER -

Relationship of endogenous levels of sex hormones to cognition and depression in frail, elderly women

Abstract

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