Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV

Mónica Manzano, Alba Talavera-Rodríguez, Elena Moreno, Nadia Madrid, María José Gosalbes, Raquel Ron, Fernando Dronda, José A. Pérez-Molina, Val F. Lanza, Jorge Díaz, Santiago Moreno, Beatriz Navia, Sergio Serrano-Villar

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation.

Original languageEnglish
Article number1221
JournalNutrients
Volume14
Issue number6
DOIs
StatePublished - 1 Mar 2022
Externally publishedYes

Keywords

  • D-dimer
  • Diet
  • Erysipelotrichaceae
  • HIV
  • Inflammatory biomarkers
  • Lachnospira
  • Microbiota
  • TNF

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