Relationship between plasma adriamycin levels and the outcome of remission induction therapy for acute nonlymphocytic leukemia

Harvey D. Preisler, Teresa Gessner, Nozar Azarnia, Wanda Bolanowska, Joshua Epstein, Amy P. Early, Peter D'Arrigo, Ralph Vogler, Lee Winton, Paul Chervenik, Robert Joyce, Howard Lee, Robert Steele, Jack Goldberg, Arlan Gottlieb, George Browman, Kenneth Miller, Hans Grunwald, Richard Larson, James Brennan

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Plasma adriamycin and adriamycinol levels were masured in 45 patients with acute nonlymphocytic leukemia 3 h after the drug was administered. A wide range of levels was found. Plasma levels increased after the administration of each of three daily doses of the drug. High plasma levels were associated with both death during remission induction therapy and, for patients who entered remission, long remissions.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalCancer Chemotherapy and Pharmacology
Volume12
Issue number2
DOIs
StatePublished - Feb 1984
Externally publishedYes

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