TY - JOUR
T1 - Relationship between Optic Nerve Head Drusen Volume and Structural and Functional Optic Nerve Damage
AU - Skaat, Alon
AU - Muylaert, Stephanie
AU - Mogil, Rachel S.
AU - Furlanetto, Rafael L.
AU - Netto, Camila F.
AU - Banik, Rudrani
AU - Liebmann, Jeffrey M.
AU - Ritch, Robert
AU - Park, Sung Chul
N1 - Funding Information:
Supported by the Young Clinician Scientist Award of the American Glaucoma Society, San Francisco, CA (S.C.P.), Empire Clinical Research Investigator Program of New York State, Albany, NY (S.C.P.), Edith C. Blum Foundation Research Fund (A.S.) and Drs Raymond and Wilma Harrison Research Fund of the New York Glaucoma Research Institute, New York, NY. J.M.L.: Grant support (Heidelberg Engineering GmbH, Topcon Medical Systems), Consultant (Carl Zeiss Meditec Inc.); R.R.: Consultant (iSonic Medical), Stock options (Diopsys); S.C.P.: Honorarium (Heidelberg Engineering, GmbH).
Publisher Copyright:
© 2017 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Purpose: The purpose of this study is to assess the relationships between optic nerve head drusen (ONHD) volume, retinal nerve fiber layer (RNFL) thickness and visual field (VF) loss. Methods: Patients with ONHD and no other ocular or systemic conditions that can affect RNFL or VF were enrolled. Serial enhanced depth imaging (EDI) optical coherence tomography (OCT) B-scans of the optic nerve head (interval between scans, 30 μm) were obtained from each participant. ONHD volume was calculated for each eye by delineating the ONHD masses in each OCT B-scan using 3-dimensional reconstruction software. Results: A total of 47 eyes (28 patients) with ONHD were included (mean age, 57±16 y). ONHD volume varied considerably [0.265±0.227 (range, 0.005 to 0.855)] mm 3. Linear and quadratic regression analyses demonstrated that ONHD volume is significantly associated with both global average RNFL thickness (linear R 2 =0.531, quadratic R 2 =0.557; P<0.001) and VF mean deviation (linear R 2 =0.519, quadratic R 2 =0.522; P<0.001). ONHD were most prevalent in the nasal quadrant (46 eyes, 98%), followed by superior, inferior and temporal quadrants [35 (74%), 30 (64%), and 16 (34%) eyes respectively]. The proportion of eyes with OCT RNFL defects (81%; 38/47 eyes) was significantly greater than that with VF defects (60%; 28/47 eyes) (P<0.001). RNFL defects were detected in 10 of the 19 eyes with no VF defects. RNFL defects were detected in all 28 eyes with VF defects. Conclusions: ONHD volume generally correlates with structural and functional optic nerve damage.
AB - Purpose: The purpose of this study is to assess the relationships between optic nerve head drusen (ONHD) volume, retinal nerve fiber layer (RNFL) thickness and visual field (VF) loss. Methods: Patients with ONHD and no other ocular or systemic conditions that can affect RNFL or VF were enrolled. Serial enhanced depth imaging (EDI) optical coherence tomography (OCT) B-scans of the optic nerve head (interval between scans, 30 μm) were obtained from each participant. ONHD volume was calculated for each eye by delineating the ONHD masses in each OCT B-scan using 3-dimensional reconstruction software. Results: A total of 47 eyes (28 patients) with ONHD were included (mean age, 57±16 y). ONHD volume varied considerably [0.265±0.227 (range, 0.005 to 0.855)] mm 3. Linear and quadratic regression analyses demonstrated that ONHD volume is significantly associated with both global average RNFL thickness (linear R 2 =0.531, quadratic R 2 =0.557; P<0.001) and VF mean deviation (linear R 2 =0.519, quadratic R 2 =0.522; P<0.001). ONHD were most prevalent in the nasal quadrant (46 eyes, 98%), followed by superior, inferior and temporal quadrants [35 (74%), 30 (64%), and 16 (34%) eyes respectively]. The proportion of eyes with OCT RNFL defects (81%; 38/47 eyes) was significantly greater than that with VF defects (60%; 28/47 eyes) (P<0.001). RNFL defects were detected in 10 of the 19 eyes with no VF defects. RNFL defects were detected in all 28 eyes with VF defects. Conclusions: ONHD volume generally correlates with structural and functional optic nerve damage.
KW - optic nerve head drusen
KW - optical coherence tomography
KW - structure-function relationship
UR - http://www.scopus.com/inward/record.url?scp=85037659022&partnerID=8YFLogxK
U2 - 10.1097/IJG.0000000000000783
DO - 10.1097/IJG.0000000000000783
M3 - Article
C2 - 29045333
AN - SCOPUS:85037659022
VL - 26
SP - 1095
EP - 1100
JO - Journal of Glaucoma
JF - Journal of Glaucoma
SN - 1057-0829
IS - 12
ER -