Relationship between gut environment, feces-to-food ratio, and androgen deficiency-induced metabolic disorders

Naoki Harada, Yukari Minami, Kazuki Hanada, Ryo Hanaoka, Yasuyuki Kobayashi, Takeshi Izawa, Takashi Sato, Shigeaki Kato, Hiroshi Inui, Ryoichi Yamaji

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Androgen action generates sex-related differences that include changes in the gut microbiota composition. Hypoandrogenism and hyperandrogenism in males and females, respectively, are associated with the prevalence of metabolic disorders. Our recent work showed that male androgen receptor knockout (ARKO) mice developed high-fat diet (HFD)-dependent sarcopenic abdominal obesity, hyperglycemia, and hepatic steatosis, leading to early death. The ARKO mice also exhibited alterations in intestinal microbiota but did not experience metabolic abnormalities when administered with antibiotics. Here, we show that time-dependent changes in feed efficiency (ratio of body weight gain to food intake) and weight of dried feces-to-food ratio could be good markers for changes in gut microbiota. Turicibacter spp., Lactobacillus spp., and L. reuteri increased in the gut in both HFD-fed ARKO and castrated mice having metabolic abnormalities. HFD-fed ARKO mice showed increased plasma levels of aspartate, but not alanine, aminotransferase. Changes in the gut microbiome appear to provoke androgen deficiency-induced metabolic diseases, leading to early mortality.

Original languageEnglish
Pages (from-to)1817719
Number of pages1
JournalGut Microbes
Volume12
Issue number1
DOIs
StatePublished - 9 Nov 2020
Externally publishedYes

Keywords

  • Apparent digestibility coefficients
  • Firmicutes/Bacteroidetes
  • feces
  • gut microflora
  • longevity
  • metabolic syndrome
  • sarcopenic obesity
  • stool
  • testosterone
  • type 2 diabetes mellitus (T2DM)

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