Abstract
Defects of DNA repair systems in cutaneous tumours are related to DNA mismatch repair genes (MLH1, MSH2, PMS1, PMS2) and Ku/70/80 genes involved in double- strand repair. In this study we investigated the statistical relationship between these systems and DNA-ploidy-related parameters in 19 naevus cell naevi, 23 lentigos maligna, 76 primary melanomas and 31 melanoma metastases, applying the correlation coefficient according to Spearman. In naevi significant correlations were found between Ku/70/80 gene expression and some ploidy-related parameters. In lentigos, additionally, some significant correlations between the expression of DNA mismatch repair genes were found. Similar results were demonstrated for primary melanomas. In metastases no one significant correlation between DNA mistmatch repair genes and Ku-genes was present. We postulate that DNA mismatch repair genes and Ku/70/80 genes are functionally independent and that some of them are able to influence ploidy-related parameters.
| Original language | English |
|---|---|
| Pages (from-to) | 317-321 |
| Number of pages | 5 |
| Journal | In Vivo |
| Volume | 16 |
| Issue number | 5 |
| State | Published - 2002 |
| Externally published | Yes |
Keywords
- DNA-mismatch repair
- Ku-proteins
- Ploidy status