Relationship between antepartum cocaine abuse, abnormal umbilical artery doppler velocimetry, and placental abruption

Iffath A. Hoskins, Deborah M. Friedman, Faith J. Frieden, Steven A. Ordorica, Bruce K. Young

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

We performed serial umbilical artery Doppler flow veloci- metry studies on 314 women and grouped them according to history of antepartum cocaine abuse, placental abruption with antepartum cocaine abuse, preterm labor with antepartum cocaine abuse, preterm labor without antepartum cocaine abuse, and controls without preterm labor or antepartum cocaine abuse. Analyses excluded twin gestation, diabetes, and hypertension. The overall incidence of deliveries at or before 36 weeks was 28% (31 of 112). Thirteen (12%) of the infants were small for gestational age (SGA) and 33 (29%) were low birth weight (LBW). Almost all subjects with a history of cocaine abuse had normal systolic-diastolic ratios (S/Ds). All patients with abruption had abnormal S/Ds, as did 14 of 64 subjects who had preterm labor and a history of cocaine abuse. No abnormal S/Ds were found in the women with preterm labor or in controls. Among cocaine-abusing women, there was a significant correlation between placental abruption and abnormal S/Ds (P < .05) and between abnormal S/Ds and the incidence of preterm birth and SGA and LBW infants.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalObstetrics and Gynecology
Volume78
Issue number2
StatePublished - Aug 1991
Externally publishedYes

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