TY - JOUR
T1 - Relation of immediate and delayed thallium-201 distribution to localization of iodine-125 antimyosin antibody in acute experimental myocardial infarction
AU - Khaw, Ban An
AU - Strauss, H. William
AU - Pohost, Gerald M.
AU - Fallon, John T.
AU - Katus, Hugo A.
AU - Haber, Edgar
N1 - Funding Information:
From the Cardiac Unit, Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, Massachusetts. This study was supported in part by U.S. Public Health Service Grants HL-17665 and HL-21751 from the National Heart, Lung, and Blood Institute, the National Institutes of Health, Bethesda, Maryland. Manuscript received November 17, 1982; revised manuscript received January 26, 1983, accepted January 28, 1983.
PY - 1983/5/1
Y1 - 1983/5/1
N2 - Thallium-201 (TI-201) distribution in acute experimental myocardial infarction (MI) (n = 18) was compared with cardiac-specific antimyosin Fab (AM-Fab) uptake, a specific marker for myocardial necrosis. When antimyosin was injected 4 hours after ligation with TI-201 administered 23 hours 55 minutes later and measurement of myocardial distribution determined 5 minutes after intravenous administration of TI-201, (1) TI-201 distribution closely correlated with microsphere regional blood flow, and (2) an inverse exponential relation to iodine-125 (I-125) AM-Fab uptake was apparent. In another group of 4 animals, TI-201 and AM-Fab were administered intravenously 4 hours after MI, and 36 hours later myocardial distribution was measured. This delayed TI-201 distribution had a close inverse linear correlation with I-125 AM-Fab uptake. This inverse linear relation also was apparent in 28-hour-old MIs in dogs (n = 4) where collateral circulation had been established. TI-201 was administered intravenously at 27 hours after MI, and TI-201 distribution was determined 1 hour later. The present study demonstrated that whereas immediate TI-201 distribution is flow-limited, delayed TI-201 distribution is a marker of cell viability which, due to prolonged circulation time and redistribution, is not flow-limited.
AB - Thallium-201 (TI-201) distribution in acute experimental myocardial infarction (MI) (n = 18) was compared with cardiac-specific antimyosin Fab (AM-Fab) uptake, a specific marker for myocardial necrosis. When antimyosin was injected 4 hours after ligation with TI-201 administered 23 hours 55 minutes later and measurement of myocardial distribution determined 5 minutes after intravenous administration of TI-201, (1) TI-201 distribution closely correlated with microsphere regional blood flow, and (2) an inverse exponential relation to iodine-125 (I-125) AM-Fab uptake was apparent. In another group of 4 animals, TI-201 and AM-Fab were administered intravenously 4 hours after MI, and 36 hours later myocardial distribution was measured. This delayed TI-201 distribution had a close inverse linear correlation with I-125 AM-Fab uptake. This inverse linear relation also was apparent in 28-hour-old MIs in dogs (n = 4) where collateral circulation had been established. TI-201 was administered intravenously at 27 hours after MI, and TI-201 distribution was determined 1 hour later. The present study demonstrated that whereas immediate TI-201 distribution is flow-limited, delayed TI-201 distribution is a marker of cell viability which, due to prolonged circulation time and redistribution, is not flow-limited.
UR - http://www.scopus.com/inward/record.url?scp=0020638868&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(83)90324-7
DO - 10.1016/0002-9149(83)90324-7
M3 - Article
C2 - 6846171
AN - SCOPUS:0020638868
SN - 0002-9149
VL - 51
SP - 1428
EP - 1432
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 8
ER -