TY - JOUR
T1 - Relation between stress and cytokine responses in inner-city mothers
AU - Gruenberg, David A.
AU - Wright, Rosalind J.
AU - Visness, Cynthia M.
AU - Jaffee, Katy F.
AU - Bloomberg, Gordon R.
AU - Cruikshank, William W.
AU - Kattan, Meyer
AU - Sandel, Megan T.
AU - Wood, Robert A.
AU - Gern, James E.
N1 - Funding Information:
Funding Sources: This project has been funded in whole or in part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health and the Department of Health and Human Services under contract numbers NO1-AI-25496, NO1-AI-25482, HHSN272200900052C, and HHSN272201000052I. Additional support was provided by the National Center for Research Resources, National Institutes of Health, under grants RR00052, M01RR00533, UL1RR025771, M01RR00071, 1UL1RR024156, and 5UL1RR024992-02.
Publisher Copyright:
© 2015 American College of Allergy, Asthma & Immunology.
PY - 2015/11
Y1 - 2015/11
N2 - Background Women in poor urban neighborhoods have high rates of stress and allergic diseases, but whether stress or stress correlates such as depression promote inflammatory and type 2 cytokine responses is unknown. Objective To examine associations among external stressors, perceived stress, depression, and peripheral blood mononuclear cell cytokine responses of mothers enrolled in the Urban Environment and Childhood Asthma Study and test the hypothesis that stress would be positively associated with type 2 and selected proinflammatory (tumor necrosis factor-α and interleukin-8) responses. Methods Questionnaire data from mothers living in 4 inner cities included information about external stress, stress perception, and depression. The external stress domains (interpersonal problems, housing, and neighborhood stress) were combined into a Composite Stressor score. Peripheral blood mononuclear cells were stimulated ex vivo and cytokine responses to innate, adaptive, and polyclonal immune stimuli were compared with stress and depression scores for 469 of the 606 study participants. Results There were no significant positive associations between Composite Stressor scores, perceived stress, or depression scores and proinflammatory or type 2 cytokine responses, and these findings were not modified by allergy or asthma status. There were some modest associations with individual stressors and cytokine responses, but no consistent relations were noted. Depression was associated with decreased responses to some stimuli, particularly dust mite. Conclusion Composite measurements of stressors, perceived stress, or depression were not positively related to proinflammatory or type 2 cytokine responses in these young urban women. These data do not support the hypothesis that these factors promote cytokine responses associated with allergy. Trial Registration Clinical Trials.gov, identifier NCT00114881.
AB - Background Women in poor urban neighborhoods have high rates of stress and allergic diseases, but whether stress or stress correlates such as depression promote inflammatory and type 2 cytokine responses is unknown. Objective To examine associations among external stressors, perceived stress, depression, and peripheral blood mononuclear cell cytokine responses of mothers enrolled in the Urban Environment and Childhood Asthma Study and test the hypothesis that stress would be positively associated with type 2 and selected proinflammatory (tumor necrosis factor-α and interleukin-8) responses. Methods Questionnaire data from mothers living in 4 inner cities included information about external stress, stress perception, and depression. The external stress domains (interpersonal problems, housing, and neighborhood stress) were combined into a Composite Stressor score. Peripheral blood mononuclear cells were stimulated ex vivo and cytokine responses to innate, adaptive, and polyclonal immune stimuli were compared with stress and depression scores for 469 of the 606 study participants. Results There were no significant positive associations between Composite Stressor scores, perceived stress, or depression scores and proinflammatory or type 2 cytokine responses, and these findings were not modified by allergy or asthma status. There were some modest associations with individual stressors and cytokine responses, but no consistent relations were noted. Depression was associated with decreased responses to some stimuli, particularly dust mite. Conclusion Composite measurements of stressors, perceived stress, or depression were not positively related to proinflammatory or type 2 cytokine responses in these young urban women. These data do not support the hypothesis that these factors promote cytokine responses associated with allergy. Trial Registration Clinical Trials.gov, identifier NCT00114881.
UR - http://www.scopus.com/inward/record.url?scp=84944897388&partnerID=8YFLogxK
U2 - 10.1016/j.anai.2015.07.021
DO - 10.1016/j.anai.2015.07.021
M3 - Article
C2 - 26409873
AN - SCOPUS:84944897388
SN - 1081-1206
VL - 115
SP - 439-445.e3
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 5
ER -