Relapsed Babesia microti Infection following Allogeneic Hematopoietic Cell Transplantation in a Patient with B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature

Joshua Rosenblatt, Annie Leung, Emily Baneman, Risa Fuller, Sarah Taimur, Alberto E. Paniz-Mondolfi, Adriana K. Malone, Laura Kirkman, Samantha E. Jacobs

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis before allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until whole-blood Babesia microti DNA was no longer detected by polymerase chain reaction, her post-transplant course was complicated by relapsed babesiosis. We investigate the potential host and parasite characteristics causing relapsing/persistent infection.

Original languageEnglish
Article numberofab323
JournalOpen Forum Infectious Diseases
Volume8
Issue number9
DOIs
StatePublished - 1 Sep 2021

Keywords

  • Babesia microti
  • babesiosis
  • hematopoietic cell transplantation
  • immunocompromised host
  • tick-borne pathogens

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