Relapsed Babesia microti Infection following Allogeneic Hematopoietic Cell Transplantation in a Patient with B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature

Joshua Rosenblatt; Annie Leung; Emily Baneman; Risa Fuller; Sarah Taimur; Alberto E. Paniz-Mondolfi; Adriana K. Malone; Laura Kirkman; Samantha E. Jacobs

doi:10.1093/ofid/ofab323

Relapsed Babesia microti Infection following Allogeneic Hematopoietic Cell Transplantation in a Patient with B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature

Joshua Rosenblatt, Annie Leung, Emily Baneman, Risa Fuller, Sarah Taimur, Alberto E. Paniz-Mondolfi, Adriana K. Malone, Laura Kirkman, Samantha E. Jacobs

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis before allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until whole-blood Babesia microti DNA was no longer detected by polymerase chain reaction, her post-transplant course was complicated by relapsed babesiosis. We investigate the potential host and parasite characteristics causing relapsing/persistent infection.

Original language	English
Article number	ofab323
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	9
DOIs	https://doi.org/10.1093/ofid/ofab323
State	Published - 1 Sep 2021

Keywords

Babesia microti
babesiosis
hematopoietic cell transplantation
immunocompromised host
tick-borne pathogens

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10.1093/ofid/ofab323

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Rosenblatt, J., Leung, A., Baneman, E., Fuller, R., Taimur, S., Paniz-Mondolfi, A. E., Malone, A. K., Kirkman, L., & Jacobs, S. E. (2021). Relapsed Babesia microti Infection following Allogeneic Hematopoietic Cell Transplantation in a Patient with B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature. Open Forum Infectious Diseases, 8(9), Article ofab323. https://doi.org/10.1093/ofid/ofab323

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title = "Relapsed Babesia microti Infection following Allogeneic Hematopoietic Cell Transplantation in a Patient with B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature",

abstract = "A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis before allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until whole-blood Babesia microti DNA was no longer detected by polymerase chain reaction, her post-transplant course was complicated by relapsed babesiosis. We investigate the potential host and parasite characteristics causing relapsing/persistent infection.",

keywords = "Babesia microti, babesiosis, hematopoietic cell transplantation, immunocompromised host, tick-borne pathogens",

author = "Joshua Rosenblatt and Annie Leung and Emily Baneman and Risa Fuller and Sarah Taimur and Paniz-Mondolfi, {Alberto E.} and Malone, {Adriana K.} and Laura Kirkman and Jacobs, {Samantha E.}",

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year = "2021",

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doi = "10.1093/ofid/ofab323",

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Rosenblatt, J, Leung, A, Baneman, E , Fuller, R , Taimur, S, Paniz-Mondolfi, AE, Malone, AK, Kirkman, L & Jacobs, SE 2021, 'Relapsed Babesia microti Infection following Allogeneic Hematopoietic Cell Transplantation in a Patient with B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature', Open Forum Infectious Diseases, vol. 8, no. 9, ofab323. https://doi.org/10.1093/ofid/ofab323

Relapsed Babesia microti Infection following Allogeneic Hematopoietic Cell Transplantation in a Patient with B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature. / Rosenblatt, Joshua; Leung, Annie; Baneman, Emily et al.
In: Open Forum Infectious Diseases, Vol. 8, No. 9, ofab323, 01.09.2021.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Relapsed Babesia microti Infection following Allogeneic Hematopoietic Cell Transplantation in a Patient with B-cell Acute Lymphoblastic Leukemia

T2 - Case Report and Review of the Literature

AU - Rosenblatt, Joshua

AU - Leung, Annie

AU - Baneman, Emily

AU - Fuller, Risa

AU - Taimur, Sarah

AU - Paniz-Mondolfi, Alberto E.

AU - Malone, Adriana K.

AU - Kirkman, Laura

AU - Jacobs, Samantha E.

PY - 2021/9/1

Y1 - 2021/9/1

N2 - A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis before allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until whole-blood Babesia microti DNA was no longer detected by polymerase chain reaction, her post-transplant course was complicated by relapsed babesiosis. We investigate the potential host and parasite characteristics causing relapsing/persistent infection.

AB - A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis before allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until whole-blood Babesia microti DNA was no longer detected by polymerase chain reaction, her post-transplant course was complicated by relapsed babesiosis. We investigate the potential host and parasite characteristics causing relapsing/persistent infection.

KW - Babesia microti

KW - babesiosis

KW - hematopoietic cell transplantation

KW - immunocompromised host

KW - tick-borne pathogens

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U2 - 10.1093/ofid/ofab323

DO - 10.1093/ofid/ofab323

M3 - Review article

AN - SCOPUS:85118251405

SN - 2328-8957

VL - 8

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 9

M1 - ofab323

ER -

Relapsed Babesia microti Infection following Allogeneic Hematopoietic Cell Transplantation in a Patient with B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature

Abstract

Keywords

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