Rejuvenating dysfunctional T cells in ovarian cancer: CD28 is the license to kill

Florian Uhlitz; Dmitriy Zamarin

doi:10.1016/j.ccell.2021.10.011

Rejuvenating dysfunctional T cells in ovarian cancer: CD28 is the license to kill

Florian Uhlitz
, Dmitriy Zamarin

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

High-grade serous ovarian cancers (HGSOCs) exhibit limited response to immune checkpoint blockade. In a new study in Cancer Cell, Duraiswamy et al. highlight intratumoral CD28 co-stimulation by myeloid-antigen-presenting cells as a key mechanism required for activation of programmed cell death receptor 1 (PD-1)⁺ tumor-infiltrating T lymphocytes during PD-1 blockade in HGSOC.

Original language	English
Pages (from-to)	1567-1569
Number of pages	3
Journal	Cancer Cell
Volume	39
Issue number	12
DOIs	https://doi.org/10.1016/j.ccell.2021.10.011
State	Published - 13 Dec 2021
Externally published	Yes

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10.1016/j.ccell.2021.10.011

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title = "Rejuvenating dysfunctional T cells in ovarian cancer: CD28 is the license to kill",

abstract = "High-grade serous ovarian cancers (HGSOCs) exhibit limited response to immune checkpoint blockade. In a new study in Cancer Cell, Duraiswamy et al. highlight intratumoral CD28 co-stimulation by myeloid-antigen-presenting cells as a key mechanism required for activation of programmed cell death receptor 1 (PD-1)+ tumor-infiltrating T lymphocytes during PD-1 blockade in HGSOC.",

author = "Florian Uhlitz and Dmitriy Zamarin",

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T2 - CD28 is the license to kill

AU - Uhlitz, Florian

AU - Zamarin, Dmitriy

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Y1 - 2021/12/13

N2 - High-grade serous ovarian cancers (HGSOCs) exhibit limited response to immune checkpoint blockade. In a new study in Cancer Cell, Duraiswamy et al. highlight intratumoral CD28 co-stimulation by myeloid-antigen-presenting cells as a key mechanism required for activation of programmed cell death receptor 1 (PD-1)+ tumor-infiltrating T lymphocytes during PD-1 blockade in HGSOC.

AB - High-grade serous ovarian cancers (HGSOCs) exhibit limited response to immune checkpoint blockade. In a new study in Cancer Cell, Duraiswamy et al. highlight intratumoral CD28 co-stimulation by myeloid-antigen-presenting cells as a key mechanism required for activation of programmed cell death receptor 1 (PD-1)+ tumor-infiltrating T lymphocytes during PD-1 blockade in HGSOC.

UR - https://www.scopus.com/pages/publications/85122771505

U2 - 10.1016/j.ccell.2021.10.011

DO - 10.1016/j.ccell.2021.10.011

M3 - Article

C2 - 34739843

AN - SCOPUS:85122771505

SN - 1535-6108

VL - 39

SP - 1567

EP - 1569

JO - Cancer Cell

JF - Cancer Cell

IS - 12

ER -

Rejuvenating dysfunctional T cells in ovarian cancer: CD28 is the license to kill

Abstract

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