Regulation of transient receptor potential (TRP) channels by phosphoinositides

Tibor Rohacs, Bernd Nilius

Research output: Contribution to journalReview articlepeer-review

105 Scopus citations

Abstract

This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are modulated by phosphoinositides. Modulation by phosphatidylinositol 4,5-biphosphate (PIP2) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4, TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels. This review describes mechanisms of modulation of TRP channels mainly by PIP2 and discusses some future challenges of this fascinating topic.

Original languageEnglish
Pages (from-to)157-168
Number of pages12
JournalPflugers Archiv European Journal of Physiology
Volume455
Issue number1
DOIs
StatePublished - Oct 2007
Externally publishedYes

Keywords

  • PIP
  • PtdIns(4, 5)P
  • TRP
  • TRPA
  • TRPC
  • TRPM
  • TRPV

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