Regulation of transient receptor potential (TRP) channels by phosphoinositides

Tibor Rohacs; Bernd Nilius

doi:10.1007/s00424-007-0275-6

Regulation of transient receptor potential (TRP) channels by phosphoinositides

Tibor Rohacs, Bernd Nilius

Research output: Contribution to journal › Review article › peer-review

104 Scopus citations

Abstract

This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are modulated by phosphoinositides. Modulation by phosphatidylinositol 4,5-biphosphate (PIP₂) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4, TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels. This review describes mechanisms of modulation of TRP channels mainly by PIP₂ and discusses some future challenges of this fascinating topic.

Original language	English
Pages (from-to)	157-168
Number of pages	12
Journal	Pflugers Archiv European Journal of Physiology
Volume	455
Issue number	1
DOIs	https://doi.org/10.1007/s00424-007-0275-6
State	Published - Oct 2007
Externally published	Yes

Keywords

PIP
PtdIns(4, 5)P
TRP
TRPA
TRPC
TRPM
TRPV

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10.1007/s00424-007-0275-6

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title = "Regulation of transient receptor potential (TRP) channels by phosphoinositides",

abstract = "This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are modulated by phosphoinositides. Modulation by phosphatidylinositol 4,5-biphosphate (PIP2) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4, TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels. This review describes mechanisms of modulation of TRP channels mainly by PIP2 and discusses some future challenges of this fascinating topic.",

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author = "Tibor Rohacs and Bernd Nilius",

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AU - Rohacs, Tibor

AU - Nilius, Bernd

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AB - This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are modulated by phosphoinositides. Modulation by phosphatidylinositol 4,5-biphosphate (PIP2) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4, TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels. This review describes mechanisms of modulation of TRP channels mainly by PIP2 and discusses some future challenges of this fascinating topic.

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KW - PtdIns(4, 5)P

KW - TRP

KW - TRPA

KW - TRPC

KW - TRPM

KW - TRPV

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JO - Pflugers Archiv European Journal of Physiology

JF - Pflugers Archiv European Journal of Physiology

IS - 1

ER -

Regulation of transient receptor potential (TRP) channels by phosphoinositides

Abstract

Keywords

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