Regulation of the ROMK channel: Interaction of the ROMK with associate proteins

Wenhui Wang

Research output: Contribution to journalShort surveypeer-review

37 Scopus citations

Abstract

The ROMK channel plays an important role in K recycling in the thick ascending limb (TAL) and K secretion in the cortical collecting duct (CCD). A large body of evidence indicates that the ROMK channel is a key component of the native K secretory channel identified in the apical membrane of the TAL and the CCD. Although the ROMK channel shares several key regulatory mechanisms with the native K secretory channel in a variety of respects, differences in the channel modulatory mechanism are clearly present between the ROMK channel and the native K secretory channel. Therefore, it is possible that additional associate proteins are required to interact with the ROMK channel to assemble the native K secretory channel. This notion is supported by recent reports showing that cystic fibrosis transmembrane conductance regulator (CFTR) and A kinase anchoring proteins (AKAP) interact with the ROMK channels to restore the response to ATP sensitivity and protein kinase A stimulation. This review is an attempt to summarize the up-to-date progress regarding the interaction between the ROMK channel and the associate proteins in forming the native K secretory channel.

Original languageEnglish
Pages (from-to)F826-F831
JournalAmerican Journal of Physiology - Renal Physiology
Volume277
Issue number6 46-6
DOIs
StatePublished - Dec 1999
Externally publishedYes

Keywords

  • A kinase anchoring protein
  • Adenosine 5'-triphosphate-sensitive potassium channel
  • Cystic fibrosis transmembrane conductance regulator
  • Protein kinase A

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