Regulation of the protein stability of EMT transcription factors

V. M. Díaz; R. Viñas-Castells; A. García De Herreros

doi:10.4161/19336918.2014.969998

Regulation of the protein stability of EMT transcription factors

V. M. Díaz, R. Viñas-Castells, A. García De Herreros

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

The epithelial to mesenchymal transition (EMT) consists of a rapid change of cell phenotype, characterized by the loss of epithelial characteristics and the acquisition of a more invasive phenotype. Transcription factors regulating EMT (Snail, Twist and Zeb) are extremely labile proteins, rapidly degraded by the proteasome system. In this review we analyze the current mechanisms controlling degradation of EMT transcription factors, focusing on the role of new E3 ubiquitin-ligases involved in EMT. We also summarize the regulation of the stability of these EMT transcription factors, specially observed in different stress conditions, such as hypoxia, chemotherapeutic drugs, oxidative stress or γ-irradiation.

Original language	English
Pages (from-to)	418-428
Number of pages	11
Journal	Cell Adhesion and Migration
Volume	8
Issue number	4
DOIs	https://doi.org/10.4161/19336918.2014.969998
State	Published - 1 Jul 2014

Keywords

EMT
F-box
Hypoxia
Proteasome
Snail1
Stress
Ubiquitination

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10.4161/19336918.2014.969998

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title = "Regulation of the protein stability of EMT transcription factors",

abstract = "The epithelial to mesenchymal transition (EMT) consists of a rapid change of cell phenotype, characterized by the loss of epithelial characteristics and the acquisition of a more invasive phenotype. Transcription factors regulating EMT (Snail, Twist and Zeb) are extremely labile proteins, rapidly degraded by the proteasome system. In this review we analyze the current mechanisms controlling degradation of EMT transcription factors, focusing on the role of new E3 ubiquitin-ligases involved in EMT. We also summarize the regulation of the stability of these EMT transcription factors, specially observed in different stress conditions, such as hypoxia, chemotherapeutic drugs, oxidative stress or γ-irradiation.",

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AU - Viñas-Castells, R.

AU - De Herreros, A. García

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AB - The epithelial to mesenchymal transition (EMT) consists of a rapid change of cell phenotype, characterized by the loss of epithelial characteristics and the acquisition of a more invasive phenotype. Transcription factors regulating EMT (Snail, Twist and Zeb) are extremely labile proteins, rapidly degraded by the proteasome system. In this review we analyze the current mechanisms controlling degradation of EMT transcription factors, focusing on the role of new E3 ubiquitin-ligases involved in EMT. We also summarize the regulation of the stability of these EMT transcription factors, specially observed in different stress conditions, such as hypoxia, chemotherapeutic drugs, oxidative stress or γ-irradiation.

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KW - Proteasome

KW - Snail1

KW - Stress

KW - Ubiquitination

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Regulation of the protein stability of EMT transcription factors

Abstract

Keywords

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