Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers

Yao E. Wang, Olivier Pernet, Benhur Lee

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Nucleocytoplasmic trafficking of many cellular proteins is regulated by nuclear import/export signals as well as post-translational modifications such as covalent conjugation of ubiquitin and small ubiquitin-related modifiers (SUMOs). Ubiquitination and SUMOylation are rapid and reversible ways to modulate the intracellular localisation and function of substrate proteins. These pathways have been co-opted by some viruses, which depend on the host cell machinery to transport their proteins in and out of the nucleus. In this review, we will summarise our current knowledge on the ubiquitin/SUMO-regulated nuclear/subnuclear trafficking of cellular proteins and describe examples of viral exploitation of these pathways.

Original languageEnglish
Pages (from-to)121-138
Number of pages18
JournalBiology of the Cell
Volume104
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

Keywords

  • Post-translational modification
  • Proteasomes/ubiquitin
  • Protein sorting/trafficking/targeting
  • Viruses

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