Regulation of the cold-sensing TRPM8 channels by phosphoinositides and Gq-coupled receptors

Luyu Liu; Tibor Rohacs

doi:10.1080/19336950.2020.1734266

Regulation of the cold-sensing TRPM8 channels by phosphoinositides and G_q-coupled receptors

Luyu Liu, Tibor Rohacs

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P₂]. This review discusses recent findings on the role of PI(4,5)P₂ and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on the role of PI(4,5)P₂ in Ca²⁺ dependent desensitization/adaptation of TRPM8 activity, and recent advances in the structural basis of how this lipid binds to TRPM8.

Original language	English
Pages (from-to)	79-86
Number of pages	8
Journal	Channels
Volume	14
Issue number	1
DOIs	https://doi.org/10.1080/19336950.2020.1734266
State	Published - 1 Jan 2020
Externally published	Yes

Keywords

G-alpha-q
GPCR
PIP2
TRPM8
phosphoinositides

Access to Document

10.1080/19336950.2020.1734266

Cite this

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title = "Regulation of the cold-sensing TRPM8 channels by phosphoinositides and Gq-coupled receptors",

abstract = "The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. This review discusses recent findings on the role of PI(4,5)P2 and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on the role of PI(4,5)P2 in Ca2+ dependent desensitization/adaptation of TRPM8 activity, and recent advances in the structural basis of how this lipid binds to TRPM8.",

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AU - Rohacs, Tibor

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AB - The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. This review discusses recent findings on the role of PI(4,5)P2 and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on the role of PI(4,5)P2 in Ca2+ dependent desensitization/adaptation of TRPM8 activity, and recent advances in the structural basis of how this lipid binds to TRPM8.

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