Regulation of phagocytosis and [Ca2+]i flux by distinct regions of an Fc receptor

Joseph A. Odin, Jeffrey C. Edberg, Catherine J. Painter, Robert P. Kimberly, Jay C. Unkeless

Research output: Contribution to journalArticlepeer-review

136 Scopus citations


The binding of multivalent immunoglobulin G complexes to Fc receptors (FcγRs) on macrophages activates multiple immune functions. A murine macrophage cell line, but not a fibroblast cell line, that was transfected with human FcγRIIA mediated phagocytosis and an intracellular Ca2+ concentration ([Ca2+]i) flux upon cross-linking of human FcγRIIA. Transfected macrophages that expressed a truncated receptor lacking 17 carboxy-terminal amino acids phagocytosed small antibody complexes. However, only wild-type transfectants phagocytosed labeled erythrocytes and fluxed [Ca2+]i. Thus, the cytoplasmic domain of human FcγRIIA contains distinct functional regions.

Original languageEnglish
Pages (from-to)1785-1788
Number of pages4
Issue number5039
StatePublished - 1991


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