Regulation of FSH receptor promoter activation in the osteoclast

Samir Zaidi; Ling Ling Zhu; Rajesh Mali; Jameel Iqbal; Guozhe Yang; Mone Zaidi; Li Sun

doi:10.1016/j.bbrc.2007.07.081

Regulation of FSH receptor promoter activation in the osteoclast

Samir Zaidi, Ling Ling Zhu, Rajesh Mali, Jameel Iqbal, Guozhe Yang, Mone Zaidi, Li Sun

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We have shown recently that FSH stimulates osteoclast formation and function by a direct action on a G_i-coupled FSH receptor (FSHR). Here, we report properties of the mouse FSH receptor promoter in the context of its activation in RAW-C3 osteoclast precursor macrophages. Basal promoter activity was low, but was significantly stimulated by receptor activator for NF-κB-ligand (RANK-L), a critical osteoclastogenic and pro-resorptive cytokine. In contrast, FSH dampened FSHR promoter activation, while estrogen had no effect. We surmise that the FSHR expression is regulated distinctly in the osteoclast, and differently from other cells, such as the ovarian follicular and Leydig cells.

Original language	English
Pages (from-to)	910-915
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	361
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2007.07.081
State	Published - 5 Oct 2007

Keywords

Estrogen
Follicle stimulating hormone receptor promoter
Osteoclast

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10.1016/j.bbrc.2007.07.081

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title = "Regulation of FSH receptor promoter activation in the osteoclast",

abstract = "We have shown recently that FSH stimulates osteoclast formation and function by a direct action on a Gi-coupled FSH receptor (FSHR). Here, we report properties of the mouse FSH receptor promoter in the context of its activation in RAW-C3 osteoclast precursor macrophages. Basal promoter activity was low, but was significantly stimulated by receptor activator for NF-κB-ligand (RANK-L), a critical osteoclastogenic and pro-resorptive cytokine. In contrast, FSH dampened FSHR promoter activation, while estrogen had no effect. We surmise that the FSHR expression is regulated distinctly in the osteoclast, and differently from other cells, such as the ovarian follicular and Leydig cells.",

keywords = "Estrogen, Follicle stimulating hormone receptor promoter, Osteoclast",

author = "Samir Zaidi and Zhu, {Ling Ling} and Rajesh Mali and Jameel Iqbal and Guozhe Yang and Mone Zaidi and Li Sun",

note = "Funding Information: We gratefully acknowledge support from the National Institutes of Health (AG14907, DK70526, AG23176, to M.Z.) and an MSTP Institutional grant (to Mount Sinai). J.I. won the Anthony Means Award from the Endocrine Society and S.L. won the Award for Outstanding Research in the Pathophysiology of Osteoporosis from the American Society for Bone and Mineral Research.",

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AU - Zaidi, Samir

AU - Zhu, Ling Ling

AU - Mali, Rajesh

AU - Iqbal, Jameel

AU - Yang, Guozhe

AU - Zaidi, Mone

AU - Sun, Li

N1 - Funding Information: We gratefully acknowledge support from the National Institutes of Health (AG14907, DK70526, AG23176, to M.Z.) and an MSTP Institutional grant (to Mount Sinai). J.I. won the Anthony Means Award from the Endocrine Society and S.L. won the Award for Outstanding Research in the Pathophysiology of Osteoporosis from the American Society for Bone and Mineral Research.

PY - 2007/10/5

Y1 - 2007/10/5

N2 - We have shown recently that FSH stimulates osteoclast formation and function by a direct action on a Gi-coupled FSH receptor (FSHR). Here, we report properties of the mouse FSH receptor promoter in the context of its activation in RAW-C3 osteoclast precursor macrophages. Basal promoter activity was low, but was significantly stimulated by receptor activator for NF-κB-ligand (RANK-L), a critical osteoclastogenic and pro-resorptive cytokine. In contrast, FSH dampened FSHR promoter activation, while estrogen had no effect. We surmise that the FSHR expression is regulated distinctly in the osteoclast, and differently from other cells, such as the ovarian follicular and Leydig cells.

AB - We have shown recently that FSH stimulates osteoclast formation and function by a direct action on a Gi-coupled FSH receptor (FSHR). Here, we report properties of the mouse FSH receptor promoter in the context of its activation in RAW-C3 osteoclast precursor macrophages. Basal promoter activity was low, but was significantly stimulated by receptor activator for NF-κB-ligand (RANK-L), a critical osteoclastogenic and pro-resorptive cytokine. In contrast, FSH dampened FSHR promoter activation, while estrogen had no effect. We surmise that the FSHR expression is regulated distinctly in the osteoclast, and differently from other cells, such as the ovarian follicular and Leydig cells.

KW - Estrogen

KW - Follicle stimulating hormone receptor promoter

KW - Osteoclast

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EP - 915

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

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ER -

Regulation of FSH receptor promoter activation in the osteoclast

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Keywords

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