Regulation of dopamine D2 receptor mRNA expression in the olfactory tubercle by cocaine

Christina Spyraki; Stuart C. Sealfon

doi:10.1016/0169-328X(93)90131-8

Regulation of dopamine D₂ receptor mRNA expression in the olfactory tubercle by cocaine

Christina Spyraki
, Stuart C. Sealfon

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The influence of acute and chronic cocaine treatment on the expression of dopamine D₂ receptor (D₂R) mRNA was examined in the rat basal ganglia by in situ hybridization histochemistry. No significant alterations in D₂R mRNA levels were observed in the striatum or the nucleus accumbens following acute or chronic cocaine. In the olfactory tubercle, acute cocaine (20 and 40 mg/kg, i.p.) was found to decrease D₂R mRNA expression. Chronic cocaine (20 mg/kg, i.p. × 15 days), however, produced an increase in D₂R mRNA levels in this region which was detected 24 h, but not 7 days after withdrawal. Acute and chronic cocaine have different effects on the regulation of D₂R gene expression in the olfactory tubercle.

Original language	English
Pages (from-to)	313-317
Number of pages	5
Journal	Molecular Brain Research
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/0169-328X(93)90131-8
State	Published - Sep 1993

Keywords

Cocaine
Dopamine receptor
In situ hybridization
Nucleus accumbens
Olfactory tubercle
Striatum

Access to Document

10.1016/0169-328X(93)90131-8

Cite this

@article{f380231a263643ab8ffe1da9143eb215,

title = "Regulation of dopamine D2 receptor mRNA expression in the olfactory tubercle by cocaine",

abstract = "The influence of acute and chronic cocaine treatment on the expression of dopamine D2 receptor (D2R) mRNA was examined in the rat basal ganglia by in situ hybridization histochemistry. No significant alterations in D2R mRNA levels were observed in the striatum or the nucleus accumbens following acute or chronic cocaine. In the olfactory tubercle, acute cocaine (20 and 40 mg/kg, i.p.) was found to decrease D2R mRNA expression. Chronic cocaine (20 mg/kg, i.p. {\texttimes} 15 days), however, produced an increase in D2R mRNA levels in this region which was detected 24 h, but not 7 days after withdrawal. Acute and chronic cocaine have different effects on the regulation of D2R gene expression in the olfactory tubercle.",

keywords = "Cocaine, Dopamine receptor, In situ hybridization, Nucleus accumbens, Olfactory tubercle, Striatum",

author = "Christina Spyraki and Sealfon, \{Stuart C.\}",

note = "Funding Information: Acknowledgments. We thank Dr. James L. Roberts for critical reading of the manuscript. Supported by a grant from the Aaron Diamond Foundation.",

year = "1993",

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doi = "10.1016/0169-328X(93)90131-8",

language = "English",

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journal = "Molecular Brain Research",

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TY - JOUR

T1 - Regulation of dopamine D2 receptor mRNA expression in the olfactory tubercle by cocaine

AU - Spyraki, Christina

AU - Sealfon, Stuart C.

N1 - Funding Information: Acknowledgments. We thank Dr. James L. Roberts for critical reading of the manuscript. Supported by a grant from the Aaron Diamond Foundation.

PY - 1993/9

Y1 - 1993/9

N2 - The influence of acute and chronic cocaine treatment on the expression of dopamine D2 receptor (D2R) mRNA was examined in the rat basal ganglia by in situ hybridization histochemistry. No significant alterations in D2R mRNA levels were observed in the striatum or the nucleus accumbens following acute or chronic cocaine. In the olfactory tubercle, acute cocaine (20 and 40 mg/kg, i.p.) was found to decrease D2R mRNA expression. Chronic cocaine (20 mg/kg, i.p. × 15 days), however, produced an increase in D2R mRNA levels in this region which was detected 24 h, but not 7 days after withdrawal. Acute and chronic cocaine have different effects on the regulation of D2R gene expression in the olfactory tubercle.

AB - The influence of acute and chronic cocaine treatment on the expression of dopamine D2 receptor (D2R) mRNA was examined in the rat basal ganglia by in situ hybridization histochemistry. No significant alterations in D2R mRNA levels were observed in the striatum or the nucleus accumbens following acute or chronic cocaine. In the olfactory tubercle, acute cocaine (20 and 40 mg/kg, i.p.) was found to decrease D2R mRNA expression. Chronic cocaine (20 mg/kg, i.p. × 15 days), however, produced an increase in D2R mRNA levels in this region which was detected 24 h, but not 7 days after withdrawal. Acute and chronic cocaine have different effects on the regulation of D2R gene expression in the olfactory tubercle.

KW - Cocaine

KW - Dopamine receptor

KW - In situ hybridization

KW - Nucleus accumbens

KW - Olfactory tubercle

KW - Striatum

UR - https://www.scopus.com/pages/publications/0027237636

U2 - 10.1016/0169-328X(93)90131-8

DO - 10.1016/0169-328X(93)90131-8

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AN - SCOPUS:0027237636

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SP - 313

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JO - Molecular Brain Research

JF - Molecular Brain Research

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