Regulation of chromatin and gene expression by metabolic enzymes and metabolites

Xinjian Li, Gabor Egervari, Yugang Wang, Shelley L. Berger, Zhimin Lu

Research output: Contribution to journalReview articlepeer-review

180 Scopus citations

Abstract

Metabolism and gene expression, which are two fundamental biological processes that are essential to all living organisms, reciprocally regulate each other to maintain homeostasis and regulate cell growth, survival and differentiation. Metabolism feeds into the regulation of gene expression via metabolic enzymes and metabolites, which can modulate chromatin directly or indirectly — through regulation of the activity of chromatin trans-acting proteins, including histone-modifying enzymes, chromatin-remodelling complexes and transcription regulators. Deregulation of these metabolic activities has been implicated in human diseases, prominently including cancer.

Original languageEnglish
Pages (from-to)563-578
Number of pages16
JournalNature Reviews Molecular Cell Biology
Volume19
Issue number9
DOIs
StatePublished - 1 Sep 2018
Externally publishedYes

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