Regulation of cancer cell survival, migration, and invasion by twist: AKT2 comes to interplay

George Z. Cheng, Weizhou Zhang, Lu Hai Wang

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations

Abstract

Metastasis, the foremost cause of mortality in cancer patients, is increasingly recognized as a coordinated biological process. The multistep process of metastasis posts difficulty in studying its mechanism and molecular basis. Recent works have shown that the basic helix-loop-helix transcriptional factor Twist and the serine/threonine kinase AKT play pivotal roles in tumor development and progression. Our recent study has shown that AKT2 is a transcriptional regulatory target of Twist and acts downstream of Twist to promote cancer cell survival, migration, and invasion. Functional convergence of Twist and AKT2 underscores the importance of this signaling pathway in tumor development and progression and as a potential therapeutic target.

Original languageEnglish
Pages (from-to)957-960
Number of pages4
JournalCancer Research
Volume68
Issue number4
DOIs
StatePublished - 15 Feb 2008
Externally publishedYes

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