TY - JOUR
T1 - Regulating trained immunity with nanomedicine
AU - van Leent, Mandy M.T.
AU - Priem, Bram
AU - Schrijver, David P.
AU - de Dreu, Anne
AU - Hofstraat, Stijn R.J.
AU - Zwolsman, Robby
AU - Beldman, Thijs J.
AU - Netea, Mihai G.
AU - Mulder, Willem J.M.
N1 - Funding Information:
This work was supported by National Institutes of Health (NIH) grants R01 HL144072, R01 CA220234, and P01 HL131478, as well as a Vici grant from the Dutch Research Council NWO and a European Research Council (ERC) Advanced Grant (no. 101019807) (all to W.J.M.M.). M.G.N. was supported by a Spinoza grant from the Netherlands Organization for Scientific Research and an ERC Advanced Grant (no. 833247).
Funding Information:
This work was supported by National Institutes of Health (NIH) grants R01 HL144072, R01 CA220234, and P01 HL131478, as well as a Vici grant from the Dutch Research Council NWO and a European Research Council (ERC) Advanced Grant (no. 101019807) (all to W.J.M.M.). M.G.N. was supported by a Spinoza grant from the Netherlands Organization for Scientific Research and an ERC Advanced Grant (no. 833247).
Publisher Copyright:
© 2022, Springer Nature Limited.
PY - 2022/6
Y1 - 2022/6
N2 - Trained immunity refers to a hyperresponsive functional state of the innate immune system, which is induced by certain stimuli, such as infections or vaccination. Trained immunity plays a key part in a variety of diseases, including cancer and inflammation, and is regulated through epigenetic and metabolic reprogramming of haematopoietic stem and progenitor cells in the bone marrow, giving rise to hyperactive myeloid cells. Nanomaterials inherently interact with phagocytic myeloid cells and are thus ideal platforms with which to regulate trained immunity. In this Review, we discuss the key pathways of trained immunity and investigate nanomedicine strategies to therapeutically regulate trained immunity. Nanomedicine can be applied not only to induce trained immunity to treat cancer or to enhance resistance to infections, but also to manage hyperinflammation and maladaptive trained immunity in a variety of clinical scenarios. We conclude with an outlook to future possibilities and some remaining challenges for nanomedicine approaches in trained immunity regulation.
AB - Trained immunity refers to a hyperresponsive functional state of the innate immune system, which is induced by certain stimuli, such as infections or vaccination. Trained immunity plays a key part in a variety of diseases, including cancer and inflammation, and is regulated through epigenetic and metabolic reprogramming of haematopoietic stem and progenitor cells in the bone marrow, giving rise to hyperactive myeloid cells. Nanomaterials inherently interact with phagocytic myeloid cells and are thus ideal platforms with which to regulate trained immunity. In this Review, we discuss the key pathways of trained immunity and investigate nanomedicine strategies to therapeutically regulate trained immunity. Nanomedicine can be applied not only to induce trained immunity to treat cancer or to enhance resistance to infections, but also to manage hyperinflammation and maladaptive trained immunity in a variety of clinical scenarios. We conclude with an outlook to future possibilities and some remaining challenges for nanomedicine approaches in trained immunity regulation.
UR - http://www.scopus.com/inward/record.url?scp=85124367815&partnerID=8YFLogxK
U2 - 10.1038/s41578-021-00413-w
DO - 10.1038/s41578-021-00413-w
M3 - Review article
AN - SCOPUS:85124367815
VL - 7
SP - 465
EP - 481
JO - Nature Reviews Materials
JF - Nature Reviews Materials
SN - 2058-8437
IS - 6
ER -