Registering cortical surfaces based on whole-brain structural connectivity and continuous connectivity analysis

Boris Gutman, Cassandra Leonardo, Neda Jahanshad, Derrek Hibar, Kristian Eschenburg, Talia Nir, Julio Villalon, Paul Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

10 Scopus citations

Abstract

We present a framework for registering cortical surfaces based on tractography-informed structural connectivity. We define connectivity as a continuous kernel on the product space of the cortex, and develop a method for estimating this kernel from tractography fiber models. Next, we formulate the kernel registration problem, and present a means to non-linearly register two brains' continuous connectivity profiles. We apply theoretical results from operator theory to develop an algorithm for decomposing the connectome into its shared and individual components. Lastly, we extend two discrete connectivity measures to the continuous case, and apply our framework to 98 Alzheimer's patients and controls. Our measures show significant differences between the two groups.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention, MICCAI 2014 - 17th International Conference, Proceedings
PublisherSpringer Verlag
Pages161-168
Number of pages8
EditionPART 3
ISBN (Print)9783319104423
DOIs
StatePublished - 2014
Externally publishedYes
Event17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014 - Boston, MA, United States
Duration: 14 Sep 201418 Sep 2014

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 3
Volume8675 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014
Country/TerritoryUnited States
CityBoston, MA
Period14/09/1418/09/14

Keywords

  • Connectivity Analysis
  • Cortical Surface Registration
  • Data Fusion
  • Diffusion MRI

Fingerprint

Dive into the research topics of 'Registering cortical surfaces based on whole-brain structural connectivity and continuous connectivity analysis'. Together they form a unique fingerprint.

Cite this