Regional myocardial substrate uptake in hypertensive rats: A quantitative autoradiographic measurement

Yoshiharu Yonekura; A. Bertrand Brill; Prantika Som; Kazutaka Yamamoto; Suresh C. Srivastava; Junichi Iwai; David R. Elmaleh; Eli Livni; H. William Strauss; Mark M. Goodman; Furn F. Knapp

doi:10.1126/science.3975623

Regional myocardial substrate uptake in hypertensive rats: A quantitative autoradiographic measurement

Yoshiharu Yonekura, A. Bertrand Brill, Prantika Som, Kazutaka Yamamoto, Suresh C. Srivastava, Junichi Iwai, David R. Elmaleh, Eli Livni, H. William Strauss, Mark M. Goodman, Furn F. Knapp

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109 Scopus citations

Abstract

Severe hypertension causes global and regional changes in myocardial perfusion and substrate utilization. Regional perfusion and fatty acid utilization were evaluated by dual-tracer autoradiography in normotensive and hypertensive rats of the Dahl strain. The regional distributions of perfusion and fatty acid utilization were homogeneous in normotensive rats. Severe hypertension was associated with a homogeneous pattern of regional perfusion, but fatty acid utilization was focally decreased in the free wall of the left ventricle. The decrease in fatty acid uptake was associated with a concomitant increase in glucose utilization. These findings suggest that severe hypertension is associated with uniform myocardial perfusion and focal alterations in the substrates used for the performance of myocardial work.

Original language	English
Pages (from-to)	1494-1496
Number of pages	3
Journal	Science
Volume	227
Issue number	4693
DOIs	https://doi.org/10.1126/science.3975623
State	Published - 1985
Externally published	Yes

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@article{e364eb102d874173a06dccc411f02cba,

title = "Regional myocardial substrate uptake in hypertensive rats: A quantitative autoradiographic measurement",

abstract = "Severe hypertension causes global and regional changes in myocardial perfusion and substrate utilization. Regional perfusion and fatty acid utilization were evaluated by dual-tracer autoradiography in normotensive and hypertensive rats of the Dahl strain. The regional distributions of perfusion and fatty acid utilization were homogeneous in normotensive rats. Severe hypertension was associated with a homogeneous pattern of regional perfusion, but fatty acid utilization was focally decreased in the free wall of the left ventricle. The decrease in fatty acid uptake was associated with a concomitant increase in glucose utilization. These findings suggest that severe hypertension is associated with uniform myocardial perfusion and focal alterations in the substrates used for the performance of myocardial work.",

author = "Yoshiharu Yonekura and Brill, {A. Bertrand} and Prantika Som and Kazutaka Yamamoto and Srivastava, {Suresh C.} and Junichi Iwai and Elmaleh, {David R.} and Eli Livni and Strauss, {H. William} and Goodman, {Mark M.} and Knapp, {Furn F.}",

year = "1985",

doi = "10.1126/science.3975623",

language = "English",

volume = "227",

pages = "1494--1496",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4693",

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TY - JOUR

T1 - Regional myocardial substrate uptake in hypertensive rats

T2 - A quantitative autoradiographic measurement

AU - Yonekura, Yoshiharu

AU - Brill, A. Bertrand

AU - Som, Prantika

AU - Yamamoto, Kazutaka

AU - Srivastava, Suresh C.

AU - Iwai, Junichi

AU - Elmaleh, David R.

AU - Livni, Eli

AU - Strauss, H. William

AU - Goodman, Mark M.

AU - Knapp, Furn F.

PY - 1985

Y1 - 1985

N2 - Severe hypertension causes global and regional changes in myocardial perfusion and substrate utilization. Regional perfusion and fatty acid utilization were evaluated by dual-tracer autoradiography in normotensive and hypertensive rats of the Dahl strain. The regional distributions of perfusion and fatty acid utilization were homogeneous in normotensive rats. Severe hypertension was associated with a homogeneous pattern of regional perfusion, but fatty acid utilization was focally decreased in the free wall of the left ventricle. The decrease in fatty acid uptake was associated with a concomitant increase in glucose utilization. These findings suggest that severe hypertension is associated with uniform myocardial perfusion and focal alterations in the substrates used for the performance of myocardial work.

AB - Severe hypertension causes global and regional changes in myocardial perfusion and substrate utilization. Regional perfusion and fatty acid utilization were evaluated by dual-tracer autoradiography in normotensive and hypertensive rats of the Dahl strain. The regional distributions of perfusion and fatty acid utilization were homogeneous in normotensive rats. Severe hypertension was associated with a homogeneous pattern of regional perfusion, but fatty acid utilization was focally decreased in the free wall of the left ventricle. The decrease in fatty acid uptake was associated with a concomitant increase in glucose utilization. These findings suggest that severe hypertension is associated with uniform myocardial perfusion and focal alterations in the substrates used for the performance of myocardial work.

UR - http://www.scopus.com/inward/record.url?scp=0021996925&partnerID=8YFLogxK

U2 - 10.1126/science.3975623

DO - 10.1126/science.3975623

M3 - Article

C2 - 3975623

AN - SCOPUS:0021996925

SN - 0036-8075

VL - 227

SP - 1494

EP - 1496

JO - Science

JF - Science

IS - 4693

ER -

Regional myocardial substrate uptake in hypertensive rats: A quantitative autoradiographic measurement

Abstract

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