Regional localization and characterization of a DNA segment on the long arm of chromosome 21

D. N. Cooper, S. C. Niemann, J. R. Gosden, A. R. Mitchell, A. M. Goate, G. S. Rajendran, D. A. Miller, L. Lim, J. Schmidtke

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A human genomic DNA fragment, pAM37 (HGM8; D21S22), was mapped to chromosome 21q2.1-q2.21 by in situ hybridization. This segment is therefore situated on the boundary of the "pathological region" of Down syndrome. A genomic restriction map encompassing 35 kb of chromosome 21 was derived and two restriction fragment length polymorphisms (RFLPs) were mapped and characterized. A homologous sequence was detected in the mouse genome but no homologous RNA was detected in a range of human tissues. This DNA segment will contribute to the linkage mapping of chromosome 21 and will facilitate delineation of the pathological region of Down syndrome.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalHuman Genetics
Volume75
Issue number2
DOIs
StatePublished - Feb 1987
Externally publishedYes

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