Regional distribution of ubiquinones and tocopherols in the mouse brain: Lowest content of ubiquinols in the substantia nigra

R. G. Fariello, O. Ghilardi, A. Peschechera, M. T. Ramacci, L. Angelucci

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

C57 black mice of 3 months of age were sacrificed, and their brain regionally dissected according to a protocol that strickly control for the death-freezing interval of each region.HPLC measurements of tocopherols and oxidized and reduced ubiquinones demonstrated significant regional variations.The substantia nigra had the lowest content of Q10 and a skewed ratio in favor of its oxidized form.Forebrain cholinergic nuclei had also more oxydized than reduced Q10 and in addition the lowest content of tocopherols. These findings suggest that nuclei that show neuronal depletion with age are the ones prone to oxidative stress.

Original languageEnglish
Pages (from-to)1077-1080
Number of pages4
JournalNeuropharmacology
Volume27
Issue number10
DOIs
StatePublished - Oct 1988
Externally publishedYes

Keywords

  • aging
  • cholinergic neurons
  • substantia nigra
  • ubiquinones

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