Regional distribution of glutathione reductase in the adult rat brain

Timothy S. Brannan; Howard S. Maker; Ingrid Raes; Cipora Weiss

doi:10.1016/0006-8993(80)90936-1

Regional distribution of glutathione reductase in the adult rat brain

Timothy S. Brannan, Howard S. Maker, Ingrid Raes, Cipora Weiss

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Glutathione reductase was measured in 10 selected areas of the adult rat brain. Activities varied over a 2.5-fold range. The caudate-putamen and cortical areas contained the highest activities. Several gray matter structures contained intermediate activities. The substantia nigra and the corpus callosum, a white matter structure, contained the lowest activities. The caudate-putamen, a catecholamine rich area, may produce H₂O₂ via MAO and would require glutathione reductase to recycle glutathione oxidized by glutathione peroxidase. However, the distribution of glutathione reductase activity also suggests a role in reducing oxidants formed during tissue respiration.

Original language	English
Pages (from-to)	474-477
Number of pages	4
Journal	Brain Research
Volume	200
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(80)90936-1
State	Published - 3 Nov 1980

Keywords

glutathione
glutathione reductase
peroxide metabolism

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10.1016/0006-8993(80)90936-1

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title = "Regional distribution of glutathione reductase in the adult rat brain",

abstract = "Glutathione reductase was measured in 10 selected areas of the adult rat brain. Activities varied over a 2.5-fold range. The caudate-putamen and cortical areas contained the highest activities. Several gray matter structures contained intermediate activities. The substantia nigra and the corpus callosum, a white matter structure, contained the lowest activities. The caudate-putamen, a catecholamine rich area, may produce H2O2 via MAO and would require glutathione reductase to recycle glutathione oxidized by glutathione peroxidase. However, the distribution of glutathione reductase activity also suggests a role in reducing oxidants formed during tissue respiration.",

keywords = "glutathione, glutathione reductase, peroxide metabolism",

author = "Brannan, \{Timothy S.\} and Maker, \{Howard S.\} and Ingrid Raes and Cipora Weiss",

year = "1980",

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doi = "10.1016/0006-8993(80)90936-1",

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journal = "Brain Research",

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T1 - Regional distribution of glutathione reductase in the adult rat brain

AU - Brannan, Timothy S.

AU - Maker, Howard S.

AU - Raes, Ingrid

AU - Weiss, Cipora

PY - 1980/11/3

Y1 - 1980/11/3

N2 - Glutathione reductase was measured in 10 selected areas of the adult rat brain. Activities varied over a 2.5-fold range. The caudate-putamen and cortical areas contained the highest activities. Several gray matter structures contained intermediate activities. The substantia nigra and the corpus callosum, a white matter structure, contained the lowest activities. The caudate-putamen, a catecholamine rich area, may produce H2O2 via MAO and would require glutathione reductase to recycle glutathione oxidized by glutathione peroxidase. However, the distribution of glutathione reductase activity also suggests a role in reducing oxidants formed during tissue respiration.

AB - Glutathione reductase was measured in 10 selected areas of the adult rat brain. Activities varied over a 2.5-fold range. The caudate-putamen and cortical areas contained the highest activities. Several gray matter structures contained intermediate activities. The substantia nigra and the corpus callosum, a white matter structure, contained the lowest activities. The caudate-putamen, a catecholamine rich area, may produce H2O2 via MAO and would require glutathione reductase to recycle glutathione oxidized by glutathione peroxidase. However, the distribution of glutathione reductase activity also suggests a role in reducing oxidants formed during tissue respiration.

KW - glutathione

KW - glutathione reductase

KW - peroxide metabolism

UR - https://www.scopus.com/pages/publications/0018931509

U2 - 10.1016/0006-8993(80)90936-1

DO - 10.1016/0006-8993(80)90936-1

M3 - Article

C2 - 7417825

AN - SCOPUS:0018931509

SN - 0006-8993

VL - 200

SP - 474

EP - 477

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Regional distribution of glutathione reductase in the adult rat brain

Abstract

Keywords

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