Regional Distribution of Catalase in the Adult Rat Brain

Timothy S. Brannan; Howard S. Maker; Ingrid P. Raes

doi:10.1111/j.1471-4159.1981.tb02411.x

Regional Distribution of Catalase in the Adult Rat Brain

Timothy S. Brannan, Howard S. Maker, Ingrid P. Raes

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

Catalase activity was measured in 11 areas of perfused adult rat brain. The hypothalamus and substantia nigra contained the highest activities. The corpus callosum. a white‐matter structure, contained intermediate activity. The caudate‐putamen and frontal cortex contained the lowest activities. Regional catalase bears some relationship to the reported distribution of microperoxisomes, but considerable activity is present in areas with few microperoxisomes. Catalase may function as one of the systems detoxifying H₂O₂ formed in CNS amine metabolism.

Original language	English
Pages (from-to)	307-309
Number of pages	3
Journal	Journal of Neurochemistry
Volume	36
Issue number	1
DOIs	https://doi.org/10.1111/j.1471-4159.1981.tb02411.x
State	Published - Jan 1981

Keywords

Amine metabolism
Catalase
Hydrogen peroxide
Regional distribution

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10.1111/j.1471-4159.1981.tb02411.x

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AB - Catalase activity was measured in 11 areas of perfused adult rat brain. The hypothalamus and substantia nigra contained the highest activities. The corpus callosum. a white‐matter structure, contained intermediate activity. The caudate‐putamen and frontal cortex contained the lowest activities. Regional catalase bears some relationship to the reported distribution of microperoxisomes, but considerable activity is present in areas with few microperoxisomes. Catalase may function as one of the systems detoxifying H2O2 formed in CNS amine metabolism.

KW - Amine metabolism

KW - Catalase

KW - Hydrogen peroxide

KW - Regional distribution

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Regional Distribution of Catalase in the Adult Rat Brain

Abstract

Keywords

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