Regional Distribution of Aromatase in the Human Brain

Anat Biegon; Joanna Fowler; Sunny Kim; Jean Logan; Deborah Pareto; Gene Jack Wang

doi:10.1093/acprof:oso/9780199841196.003.0005

Regional Distribution of Aromatase in the Human Brain

Anat Biegon
, Joanna Fowler
, Sunny Kim
, Jean Logan
, Deborah Pareto
, Gene Jack Wang

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Aromatase catalyzes the last step in the biosynthesis of estrogens in humans as well as in other species. The regional distribution and cellular and subcellular expression of human brain aromatase have been studied using different complementary methodologies, including in vivo positron emission tomography, immunohistochemistry, polymerase chain reaction (PCR), and enzyme activity assays. The regional and cellular distribution of human brain aromatase have some unique features compared with other primate and nonprimate species, including high levels in thalamus and more ubiquitous distribution among different cell types. These differences may underlie the involvement of estrogen in a range of nonreproductive behaviors and functions unique to humans.

Original language	English
Title of host publication	Brain Aromatase, Estrogens, and Behavior
Publisher	Oxford University Press
ISBN (Electronic)	9780199979837
ISBN (Print)	9780199841196
DOIs	https://doi.org/10.1093/acprof:oso/9780199841196.003.0005
State	Published - 24 Jan 2013
Externally published	Yes

Keywords

Aromatase
CYP19A1
Human brain
PET

Access to Document

10.1093/acprof:oso/9780199841196.003.0005

Cite this

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title = "Regional Distribution of Aromatase in the Human Brain",

abstract = "Aromatase catalyzes the last step in the biosynthesis of estrogens in humans as well as in other species. The regional distribution and cellular and subcellular expression of human brain aromatase have been studied using different complementary methodologies, including in vivo positron emission tomography, immunohistochemistry, polymerase chain reaction (PCR), and enzyme activity assays. The regional and cellular distribution of human brain aromatase have some unique features compared with other primate and nonprimate species, including high levels in thalamus and more ubiquitous distribution among different cell types. These differences may underlie the involvement of estrogen in a range of nonreproductive behaviors and functions unique to humans.",

keywords = "Aromatase, CYP19A1, Human brain, PET",

author = "Anat Biegon and Joanna Fowler and Sunny Kim and Jean Logan and Deborah Pareto and Wang, \{Gene Jack\}",

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T1 - Regional Distribution of Aromatase in the Human Brain

AU - Biegon, Anat

AU - Fowler, Joanna

AU - Kim, Sunny

AU - Logan, Jean

AU - Pareto, Deborah

AU - Wang, Gene Jack

PY - 2013/1/24

Y1 - 2013/1/24

N2 - Aromatase catalyzes the last step in the biosynthesis of estrogens in humans as well as in other species. The regional distribution and cellular and subcellular expression of human brain aromatase have been studied using different complementary methodologies, including in vivo positron emission tomography, immunohistochemistry, polymerase chain reaction (PCR), and enzyme activity assays. The regional and cellular distribution of human brain aromatase have some unique features compared with other primate and nonprimate species, including high levels in thalamus and more ubiquitous distribution among different cell types. These differences may underlie the involvement of estrogen in a range of nonreproductive behaviors and functions unique to humans.

AB - Aromatase catalyzes the last step in the biosynthesis of estrogens in humans as well as in other species. The regional distribution and cellular and subcellular expression of human brain aromatase have been studied using different complementary methodologies, including in vivo positron emission tomography, immunohistochemistry, polymerase chain reaction (PCR), and enzyme activity assays. The regional and cellular distribution of human brain aromatase have some unique features compared with other primate and nonprimate species, including high levels in thalamus and more ubiquitous distribution among different cell types. These differences may underlie the involvement of estrogen in a range of nonreproductive behaviors and functions unique to humans.

KW - Aromatase

KW - CYP19A1

KW - Human brain

KW - PET

UR - https://www.scopus.com/pages/publications/84920493369

U2 - 10.1093/acprof:oso/9780199841196.003.0005

DO - 10.1093/acprof:oso/9780199841196.003.0005

M3 - Chapter

AN - SCOPUS:84920493369

SN - 9780199841196

BT - Brain Aromatase, Estrogens, and Behavior

PB - Oxford University Press

ER -

Regional Distribution of Aromatase in the Human Brain

Abstract

Keywords

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