Regional Distribution of Aromatase in the Human Brain

Anat Biegon, Joanna Fowler, Sunny Kim, Jean Logan, Deborah Pareto, Gene Jack Wang

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Aromatase catalyzes the last step in the biosynthesis of estrogens in humans as well as in other species. The regional distribution and cellular and subcellular expression of human brain aromatase have been studied using different complementary methodologies, including in vivo positron emission tomography, immunohistochemistry, polymerase chain reaction (PCR), and enzyme activity assays. The regional and cellular distribution of human brain aromatase have some unique features compared with other primate and nonprimate species, including high levels in thalamus and more ubiquitous distribution among different cell types. These differences may underlie the involvement of estrogen in a range of nonreproductive behaviors and functions unique to humans.

Original languageEnglish
Title of host publicationBrain Aromatase, Estrogens, and Behavior
PublisherOxford University Press
ISBN (Electronic)9780199979837
ISBN (Print)9780199841196
DOIs
StatePublished - 24 Jan 2013
Externally publishedYes

Keywords

  • Aromatase
  • CYP19A1
  • Human brain
  • PET

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