Regional changes in cerebellar creatine phosphate metabolism during late maturation

Howard S. Maker, Gerard M. Lehrer, Demetra J. Silides, Cipora Weiss

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13 Scopus citations


The activity of creatine kinase, the steady-state level of creatine phosphate, and the rate of change of creatine phosphate during a brief period of ischemia have been studied by quantitative micromethods in the cerebellar molecular and granular layers and white matter of prepubescent and adult mice. In the neuropil-rich molecular layer there is a large increase with maturation in creatine kinase activity, creatine phosphate level, and the rate of disappearance of creatine phosphate during ischemia. In the granular layer there is a decline in creatine kinase activity with maturation but no change in creatine phosphate level or its ischemic flux. Neither creatine kinase activity nor the creatine phosphate level changes in the white matter with maturation. The differences could not be attributed to differences in lipid or cell density. The findings suggest a significant change in energy metabolism of synapse-rich areas after the apparent morphological maturation of the cerebellar cortex. This change would be obscured if histologically more complex regions are studied.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalExperimental Neurology
Issue number2
StatePublished - Feb 1973


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