Regenerating the heart: The past, present, & future

Aditya Sengupta, Raghav A. Murthy

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Coronary artery disease, with subsequent ischemic cardiomyopathy, is the leading cause of mortality worldwide. Following an ischemic insult, a remodeling process ensues that replaces damaged cardiomyocytes with fibrotic tissue, leading to further cardiomyocyte depletion, ventricular dysfunction, and eventually heart failure. Loss of cardiac muscle is especially relevant here given the limited regenerative capacity of the adult heart. The past several decades have witnessed the evolution of numerous therapeutic approaches for repairing and regenerating the heart, with varied success. Strategies include cell-based approaches such as transplantation of induced pluripotent stem cell-derived cardiomyocytes, cell-free approaches such as manipulation of cardioprotective secretory factors and direct reprogramming of resident fibroblasts, and stimulation of endogenous cardiac repair mechanisms. Overall, preclinical outcomes of cardiac regenerative therapy have not translated to clinical trials given issues with low engraftment rates and safety. Newer technologies such as genome editing and modulation of the cardiac microenvironment hold promise, but much work needs to be done before these therapies come of age.

Original languageEnglish
Title of host publicationRegenerated Organs
Subtitle of host publicationFuture Perspectives
Number of pages11
ISBN (Electronic)9780128210857
StatePublished - 1 Jan 2021


  • Coronary artery disease
  • Heart
  • Ischemic heart disease
  • Regenerating
  • Stem cell


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